Why people move (US, Washington Post) http://t.co/nXzRKRV6Lr
5:16am June 6th 2014 via Hootsuite
RT @theNCI: Mutant RAS proteins may play a role in 1/3 of all human cancers: NCI’s RAS prog http://t.co/7H8XWOApqB http://t.co/A6MUaRBx9V
12:50pm June 5th 2014 via Hootsuite in reply to
RT @GenomeNathan: Meet & join the Empowered Genome Community MT @bioitworld “... [for] Whole Genome Owners”. http://t.co/4ygCrRyiId
11:55am June 5th 2014 via Hootsuite in reply to
Reporting on findings in Neuron RT @idtdna: Double Hit for Chromatin Remodeling in #Schizophrenia Exomes http://t.co/CzipX6Nlqt
10:55am June 5th 2014 via Hootsuite in reply to
Nice contrast MT @EricTopol: WGS for severe intellectual disability http://t.co/8LRiADK2ZM @Nature #genomics http://t.co/CcMVwqmTSN
9:55am June 5th 2014 via Hootsuite in reply to
Interesting RT @Scobleizer: Here’s why I pour a LOT more time into Facebook than Twitter: https://t.co/Jm2S8HM56f
8:55am June 5th 2014 via Hootsuite in reply to
New lung ca ass’n RT @NCICancerCtrl: #BRCA Gene Can Be a #Cancer Triple Whammy, Study Finds http://t.co/ndoTl5Flol
7:50am June 5th 2014 via Hootsuite in reply to
RT @Rndubois: The Great Hamstring Saver: http://t.co/u9V2jCeEYV
6:50am June 5th 2014 via Hootsuite in reply to
Interesting ‘judges’ research RT @tienwong: 5 Habits of People With Remarkable Willpower | Inc. http://t.co/WqujXwOjAF
5:50am June 5th 2014 via Hootsuite in reply to
.@edyong209 Congratulations! (Erm, for you overachieving and making it all look so >easy<...)
3:56am June 5th 2014 via Hootsuite in reply to
.@Proteomics_Now Thanks for the mention of the new blog! A lot of work and a lot of fun. :)
1:20pm June 4th 2014 via Hootsuite in reply to
.@genomepandit You are welcome - many great talks at #ESHG14, too bad not many active in Twitter.
1:19pm June 4th 2014 via Hootsuite in reply to
.@GermSchoales Good times at #ESHG14 indeed! Look forward to #ESHG15 in Glasgow! :)
1:17pm June 4th 2014 via Hootsuite in reply to
Thank you to all at #ESHG14 for a great meeting. See you next year in Glasgow!
9:17am June 3rd 2014 via Hootsuite
Stratton: APOBEC may be directed by dsDNA breaks; tested and shown in yeast. #ESHG14
9:15am June 3rd 2014 via Hootsuite
Stratton: Kataegis always has TpCpN trinucleotides; hyperediting restricted to small area. APOBEC responsible (in yeast) #ESHG14
Stratton: Never see kataegis in the same place twice; all unique #ESHG14
9:13am June 3rd 2014 via Hootsuite
Stratton: Localized hypermut: kataegis. Rainfall plot: 2012 Cell pub http://t.co/Fj5p1w4FXa Mutations <100bp spacing, Chr6 #ESHG14
Stratton: Illustrates: 4 signatures of mismatch repair; defective BRCA1/2 homologous recombination repair; others and 'unknown'. #ESHG14
9:11am June 3rd 2014 via Hootsuite
Stratton: APOBEC3A/3B can have a 30kb deletion forming a chimeric protein; increases risk of hypermut of Sig 2; inc risk for br ca #ESHG14
9:09am June 3rd 2014 via Hootsuite
Stratton: Switching on of APOBEC - is it amplification, overexpression, or response to a virus or retrotransposon? #ESHG14
9:05am June 3rd 2014 via Hootsuite
Stratton: AID cntral role in class switch recombination at Ig loci. APOBEC3A-H mutate HIV, HBV for defense #ESHG14
9:04am June 3rd 2014 via Hootsuite
Stratton: AID/APOBEC family of cytidine deaminases DNA editing machinery at an abasic site. C-T or C-G (like in Sig 2) #ESHG14
9:03am June 3rd 2014 via Hootsuite
Stratton: Sig 2 has about 12 mut/MB in 10% of breast cancers; C-T and C-G mutations, specific contexts. TpCpA etc. #ESHG14
9:01am June 3rd 2014 via Hootsuite
Stratton: From these processes - the desire to understand mechanism. Now onto signature 2, 50% of the cancer types. #ESHG14
9:00am June 3rd 2014 via Hootsuite
Stratton: Some signatures observed in almost every cancer type, others 50%, others only one. #ESHG14
8:58am June 3rd 2014 via Hootsuite
Stratton: Great diversity of patterns, some combinations that are somewhat similar. Across 30 types of cancers shown #ESHG14
8:57am June 3rd 2014 via Hootsuite
Stratton: Showing 26 (now 30) mutational signature. "More than we expected, more causes than we know of." #ESHG14
8:56am June 3rd 2014 via Hootsuite
Stratton: Of 7,042 samples of 30 cancer types; 4.9M mutations, now look cross the landscape #ESHG14
8:54am June 3rd 2014 via Hootsuite
Stratton: 6 types of C-T base substitutions (due to adjacent bases); move out from 6 to 96 due to 2 adjacent bases. #ESHG14
Stratton: A different math problem due to many unknowns. A blind source separation problem. 1999 Nature pub http://t.co/gK4cZxhQzW #ESHG14
8:52am June 3rd 2014 via Hootsuite
Stratton: The challenge is all three types are mixed together in the 'final cancer genome'. (Nicely laid out.) #ESHG14
8:51am June 3rd 2014 via Hootsuite
Stratton:From 1 fertilized egg to cancer cell: 3 models - constant, a burst in the middle, or steady later on through the end #ESHG14
8:50am June 3rd 2014 via Hootsuite
Stratton: Since 1980's, looking at TP53; of 686 skin cancers, 60% C->T mutations due to UV. Of 167 lung ca: C->A majority #ESHG14
8:47am June 3rd 2014 via Hootsuite
Stratton: Sources of mutatation: pollutants; mistakes in cell division; UV, cigarette smoke, aflatoxin, auto-repair mechanism damage #ESHG14
8:45am June 3rd 2014 via Hootsuite
Stratton: Detection / monitoring of circ. DNA impt finding. Today: mutational processes involved. 2013 Nature http://t.co/1WuC02X9QS #ESHG14
8:43am June 3rd 2014 via Hootsuite
Stratton: There are 5-600 mutated cancer genes, many insights from cancer genome sequencing; on the order of 10K now #ESHG14
8:41am June 3rd 2014 via Hootsuite
Final session: Sir Michael Stratton (Inst. of Cancer Research, UK): Signatures of Mutational Processes in Human Cancer #ESHG14
8:40am June 3rd 2014 via Hootsuite
RT @iontorrent: This video gives a first look at the PGM Dx #ESHG14 http://t.co/OPbWpMXfym
4:50am June 3rd 2014 via Hootsuite in reply to
RT @iontorrent: Andy Felton of Ion Torrent product management gives us a quick update on PII, Ion Chef from #ESHG14 http://t.co/IOQ4lAHtT4
4:35am June 3rd 2014 via Hootsuite in reply to
RT @LIFECorporation: Quick chat about #ESHG14 poster “Digital PCR for Quant. Chimerism in Leukemia Samples” http://t.co/6DevlCBTQK http://t…
4:16am June 3rd 2014 via Hootsuite
RT @LIFECorporation: Blog: Download copies of our posters presented at #ESHG14 http://t.co/fPySWz1Pvd
12:25pm June 2nd 2014 via Hootsuite in reply to
Soranzo: Suggests that WES you miss out on biologically important (albeit rare) variation in non-coding parts of the genome #ESHG14
11:56am June 2nd 2014 via Hootsuite
Soranzo: Exomes vs. Genomes? Did the comparison for SNPs within coding regions; low freq ass'n are found in non-coding domains #ESHG14
11:55am June 2nd 2014 via Hootsuite
Soranzo: Funded to make datasets freely available. Their URL to access data here http://t.co/3CvGiEbzKA #ESHG14
11:51am June 2nd 2014 via Hootsuite
Soranzo: Novel LDLR intronic variant ID via meta-analysis of 20K GWAS samples #ESHG14
11:50am June 2nd 2014 via Hootsuite
Soranzo: Inc. accuracy of imputation via combining UK10K and TGP data; r2 significantly higher #ESHG14
11:49am June 2nd 2014 via Hootsuite
Nicole Soranzo (Wellcome Trust UK) “WGS of 4K individuals provides insight into genetic architecture of complex traits” #ESHG14
11:44am June 2nd 2014 via Hootsuite
Tweeting on behalf of @LIFECorporation the digital PCR workshop (Amber 6 & 7) #ESHG14
9:38am June 2nd 2014 via Hootsuite
#ESHG14 @LIFECorporation Digital PCR workshop starting at 1530 in the Amber 7&8 rooms - several researchers looking at cell-free DNA
9:20am June 2nd 2014 via Hootsuite
