JM:Q:Advice? A:Add value. How biotech works - very long time-frames, >10y. Acquire IP #ResearchFest
3:04pm September 22nd 2014 via Hootsuite
JM: 2013 'Reflections' on the discover of Ca19 http://t.co/qAzezDZNfV #ResearchFest
3:02pm September 22nd 2014 via Hootsuite
JM: GMI-1271 now launched clinical trial; Glycomimetics (NASDAQ:GLYC) first to go public in 2014; 34 employees #ResearchFest
3:00pm September 22nd 2014 via Hootsuite
JM: GMI-1271: targeting bone marrow microenv. for AML. E-selectin stimulates exp of genes for survival in AML blasts #ResearchFest
2:58pm September 22nd 2014 via Hootsuite
JM:Opioid analgesic reduced by 83%; very little self-administered by patients #ResearchFest
2:53pm September 22nd 2014 via Hootsuite
JM: GMI-1070 called Rivipansel P2 trial: median time to discharge reduced by 84h (expectation 24h reduction) #ResearchFest
2:52pm September 22nd 2014 via Hootsuite
JM: In '11 Pfizer invested $340M license. Looked at cell adhesion markers, activation markers inhibition, coag cascade in PI #ResearchFest
2:51pm September 22nd 2014 via Hootsuite
JM: VOC among sickle-cell sufferers, >78K hospitalizations/year, ave 6.1d visit, no treatment #ResearchFest
2:49pm September 22nd 2014 via Hootsuite
JM: Now moving to vaso-occlusion process as it involves GMI-1070; application to sickle-cell (affects >100K in US) #ResearchFest
2:48pm September 22nd 2014 via Hootsuite
JM: Carbohydrate groups although labile, can be used to help rational drug design. Replace residues, maintain interactions #ResearchFest
2:42pm September 22nd 2014 via Hootsuite
JM: Sialyl Le^a a functional tumor marker for Gastric cancer, also binding ligand for E-selectin #ResearchFest
2:40pm September 22nd 2014 via Hootsuite
JM: In 1980's, TLC plates staining with mAb's showed discovery of Siayl Le^a: CA-19-9 antigen, a Pancreatic Ca antigen #ResearchFest
2:38pm September 22nd 2014 via Hootsuite
JM: Highlights work of Victor Ginsburg, a glycobiology pioneer. 1964 PNAS: http://t.co/xNDmHSY8rJ #ResearchFest
2:36pm September 22nd 2014 via Hootsuite
John Magnani, NIDDK now GlycoMimetics. "A new source of therapeutic oppy's for treating sickle cell, cancer, & other diseases" #Research
2:31pm September 22nd 2014 via Hootsuite
BW:A:Stay optimistic and passionate. #ResearchFest
2:30pm September 22nd 2014 via Hootsuite
BW:Q:Advice? A:Be risk averse. Don't disclose anything, line up everything, file the IP, grill everyone carefully. #ResearchFest
2:29pm September 22nd 2014 via Hootsuite
BW: Keynes: "The market can stay irrational longer than you can stay solvent." Makes case for the need for continued SBIR's #ResearchFest
2:27pm September 22nd 2014 via Hootsuite
BW: His wife: "I thought it would be a Wed nite steak at the clinic. Never in my life did I think it would be farm animals" #ResearchFest
2:26pm September 22nd 2014 via Hootsuite
BW: TrophoGen's SBIR grants: $9.8M cumulative, non-diluting investment. Pages of IP and new glycosylation. #ResearchFest
2:25pm September 22nd 2014 via Hootsuite
BW: Bovine superovulation, bovine/porcine maturation. On verge of large Animal Health opportunity - stay tuned. #ResearchFest
2:22pm September 22nd 2014 via Hootsuite
BW: TrophoGen now looking at Cysteine-Knot Growth-factor Superfamily. VEGF, PDGF... many product ideas #ResearchFest
2:20pm September 22nd 2014 via Hootsuite
BW: Second-generation: now applied to unmet needs in food supply / safety. W.Mariusz Szkudlinski, licensed tech from NIH #ResearchFest
2:18pm September 22nd 2014 via Hootsuite
BW: In 1998, FDA approval. hTSH (Thyrogen) becomes a top licensing income producer for the NIH. #ResearchFest
2:17pm September 22nd 2014 via Hootsuite
BW: 1986, a Technology Transfer Act passed; thyroid treatment idea; first with Integrated Genetics, SBIR, Genzyme, PIII trial #ResearchFest
2:14pm September 22nd 2014 via Hootsuite
BW: Interest going back many years is glycloprotein hormones. Human TSH genes; sugars were very impt. #ResearchFest
2:09pm September 22nd 2014 via Hootsuite
BW: ''The main quality all entrepreneurs have in common is OPTIMISM" "..to the point of hubris..." #ResearchFest
2:06pm September 22nd 2014 via Hootsuite
Session: "Commercial development of my research discoveries". First: Bruce Weintraub, of NIDDK, then TrophoGen #ResearchFest
2:05pm September 22nd 2014 via Hootsuite
Statement on Prize for Diagnostic Devices to Identify Antimicrobial Resistant Bacterial Infections - The NIH Director http://t.co/xEiaNAmK3D
1:00pm September 22nd 2014 via Hootsuite
MH: Best therapy now is Bt injection #ResearchFest
11:41am September 22nd 2014 via Hootsuite
MH: Writer's cramp: fingers abnormally flex or extend. Repetitive activity can lead to abnormal function #ResearchFest
MH: Can be eyelid control: frequent blinking video, blepherospasm. Neck control, hand control (piano playing, 1 pinkie) #ResearchFest
11:19am September 22nd 2014 via Hootsuite
MH: Dystonia prevalent about 16.5/100K. Sustained or intermittent muscle contractions. Video of child w/difficulty walking #ResearchFest
11:18am September 22nd 2014 via Hootsuite
Mark Hallett, NINDS “Focal hand dystonia: a failure of just one highly skilled movement” #ResearchFest
11:15am September 22nd 2014 via Hootsuite
AB: Optogenetic stimulation of the prefrontal cortex, in order to decrease cocaine-seeking behavior ResearchFest
11:01am September 22nd 2014 via Hootsuite
AB: Can use it to map pathways, create new therapeutics. Cocaine: low frontal cortex activity (outcome of decisions) #ResearchFest
10:57am September 22nd 2014 via Hootsuite
AB: Optogenetics: a revolution <10y ago, selecting a group of brain cells, injecting light-sensitive protein to visuallize #ResearchFest
10:54am September 22nd 2014 via Hootsuite
AB: Testing Pavlovian in Thorase KO mice: appetitive learning is impaired; ongoing research with cocaine & synaptic plasticity #Research
10:53am September 22nd 2014 via Hootsuite
AB: Developed a cre-lox knock-out Thorase mouse, with a frozen receptor, similar to cocaine response #ResearchFest
10:51am September 22nd 2014 via Hootsuite
AB: (Chen 2008 Neuron reference: http://t.co/CphahBn0n5 about persistent LTP) #ResearchFest
10:49am September 22nd 2014 via Hootsuite
AB: Ex: Single dose of cocaine changes LTP for 5d, shown as long as 3mo. Dopamine stim. - only a few days. #ResearchFest
10:48am September 22nd 2014 via Hootsuite
AB: Drugs of abuse change responses; long-term potentiation of dopamine neurons; DOA's do change potentiation #ResearchFest
10:46am September 22nd 2014 via Hootsuite
AB: Talking about dopamine: 'the center of my universe'; most fundamental Schiz, Parkinsons, ADHD, learning memory, abuse #ResearchFest
10:44am September 22nd 2014 via Hootsuite
Next: Dr. Antonello Bonci, Sci Dir NIDA "Optogenetic approaches to understanding substance use disorders" #ResearchFest
10:43am September 22nd 2014 via Hootsuite
(FARE award winners recognized per-Institute. Great work, well deserved!) #ResearchFest
10:41am September 22nd 2014 via Hootsuite
Lucie Lowe, introd. to the Fellows Award for Res Excellence: There are about 4,000 post-docs in the intramural NIH #ResearchFest
10:32am September 22nd 2014 via Hootsuite
MT @irpatnih: Dr. Collins: #Cancer #immunotherapy breakthroughs of Dr. Rosenberg http://t.co/opNl0r3K80 #ResearchFest http://t.co/gAJslgRLu4
10:27am September 22nd 2014 via Hootsuite
FC: The NIH intramural program in 10y; gave a plug @NIHDirector on Twitter and pointed to his blog http://t.co/pyg42pCM8e #ResearchFest
10:25am September 22nd 2014 via Hootsuite
FC: Reviewing the peer-review process to examine fairness; major new grant programs (BUILD for diversity, NRMN mentoring, CEC) #ResearchFest
10:23am September 22nd 2014 via Hootsuite
FC: 'We need to do a better job to make biomedical research more appealing' to encourage under-rep'd groups #ResearchFest
10:21am September 22nd 2014 via Hootsuite
FC: Major oppotrunity: preparing a diverse and talented biomedical research workforce. Encouraging early-stage researchers #ResearchFest
10:20am September 22nd 2014 via Hootsuite
