MS:Reviewed applications of NGS through to microbiome, and impact on research fields (cancer, comparative genomics, phenotyping etc) #ASHG14
3:16pm October 19th 2014 via Hootsuite
Michael Snyder @Macrogen's lunchtime workshop: Next Generation Sequencing: A Key to New Discoveries #ASHG14
3:15pm October 19th 2014 via Hootsuite
SV+EM: But press still helps in 'more subtle' ways, in terms of outreach. Data: shared with backers and the public #ASHG14
2:48pm October 19th 2014 via Hootsuite
SV+EM:Details of budget, justification for everything. "I think you are overpaying for luciferin." Press doesn't solve funding #ASHG14
2:47pm October 19th 2014 via Hootsuite
SV+EM: https://t.co/nVBUhwQkfK is the crowdsourcing website. Recently, crowdfunding for science is growing to $45K (ave for cancer) #ASHG14
2:45pm October 19th 2014 via Hootsuite
SV+EM: 'Video was hard to make' but very effective in getting the message out #ASHG14
2:44pm October 19th 2014 via Hootsuite
SV+EM: Analysis of donors: affected families overwhelmingly supported. So: why crowd-fund? It catalyzes support. #ASHG14
2:43pm October 19th 2014 via Hootsuite
SV+EM: Crowdfunding typically spikes; 'urgency effect'; New Yorker piece 'didn't really help' #ASHG14
2:42pm October 19th 2014 via Hootsuite
SV+EM:Chart of fundraising by day (45d): @dgmacarthur and others (4min video). People helping. "If only we could get press" #ASHG14
2:41pm October 19th 2014 via Hootsuite
SV+EM: Mouse models, promising cmpd, needed funding. Thus crowdfunded last fund $8K goal, raised $17K, put into all 3 models #ASHG14
2:39pm October 19th 2014 via Hootsuite
SV + EM: Blogging a part of their scientific trajectory - http://t.co/pbniZ38Z7T and the researcher reaches out #ASHG14
SV EM: Publication in 2013 http://t.co/JjzmrzjXWN on anticipation early-onset. Refuted recently #ASHG14
2:37pm October 19th 2014 via Hootsuite
SV: (Eric now speaking) started blogging in 2012 here: http://t.co/A5zvgyOTO8 and explored prion disease treatment. Started collab. #ASHG14
2:35pm October 19th 2014 via Hootsuite
SV: Now both biology med sch students. In parallel: to raise funds http://t.co/8CHUAlWj0B #ASHG14
2:34pm October 19th 2014 via Hootsuite
SV: After testing in '11: she tested positive. 100% penetrant, onset ~50y.o. She: lawyer; He: consultant. Read up, MGH labwork now #ASHG14
2:33pm October 19th 2014 via Hootsuite
SV: ~10% prion disease is genetic; small % is acquired, majority is sporadic. Personal story: mother over 6 mos neurogen decline #ASHG14
2:31pm October 19th 2014 via Hootsuite
Sonia Vallabh & Eric Minikel (Prion Alliance) "Crowd funding: A personal quest to cure prion disease" #ASHG14
2:30pm October 19th 2014 via Hootsuite
AB:Q:New ethical paradigm for crowdsourcing? A:Samples in a cart, no effort at re-ID; 'we need to strengthen it' #ASHG14
2:28pm October 19th 2014 via Hootsuite
AB: Points to IMMPORT from NIAID http://t.co/fvtDf0Zw3M Wrapup giving credit to many NIH institutes, HHMI #ASHG14
2:26pm October 19th 2014 via Hootsuite
AB: It might not work, side effects etc. But the approach can still be applied again. 'Clinical trials are the most $ experiment' #ASHG14
2:24pm October 19th 2014 via Hootsuite
AB: Anti-depressant against SCLC; 2013 publ: http://t.co/nEXl25FQS4 15mos from prediction, to a clinical trial in humans #ASHG14
2:23pm October 19th 2014 via Hootsuite
AB:Epilepsy drug working on IBD Sci Trans Med publ http://t.co/OrVodEpTb9 showed rat colonoscopy 'this you want to outsource'! #ASHG14
2:22pm October 19th 2014 via Hootsuite
AB: Testing an ob/ob mouse with a cmpd, $9K cost for 16 mice. 'Validation methods are commoditized". In China, Maryland, WI... #ASHG14
2:20pm October 19th 2014 via Hootsuite
AB: He goes to 'Assay Depot' dot com: goes to pharmacology, name the disease, goes to ob/ob diabetes mice 'since 1951' 28d tests... #ASHG14
2:19pm October 19th 2014 via Hootsuite
AB: Illustrates gene exp activity and 'on purpose'. Sirota et al http://t.co/prw9fnx0dl of their approach #ASHG14
2:18pm October 19th 2014 via Hootsuite
AB: The true cost of drug dev: $4B-$12B (Forbes piece by @matthewherper http://t.co/m5dKx8vnBG #ASHG14
2:17pm October 19th 2014 via Hootsuite
AB: 15-18 mo from concept to private funding. New markers for pre-eclampsia. "A new model for the #postdocalypse' #ASHG14
2:15pm October 19th 2014 via Hootsuite
AB: Onto pre-eclampsia (inserted reference to Downton Abbey), spun out another company. Started with unmet need, tested #ASHG14
2:14pm October 19th 2014 via Hootsuite
AB:Medullo-blastoma cell surface marker publication, transplant rejection marker publ. cited http://t.co/EmUlzRYp7H #ASHG14
2:13pm October 19th 2014 via Hootsuite
AB: Normally discarded, not identified, it's legal to re-sell. And the hypothesis can be then tested. #ASHG14
2:11pm October 19th 2014 via Hootsuite
AB:Instead: he buys it online. 'CD45+ cells from bone marrow...' (From 'conversant bio', 'add to shopping cart') #ASHG14
2:10pm October 19th 2014 via Hootsuite
AB: (Due to inherent lability of RNA.) "ELIZAs work in the desert". For AML Dx: Stanford saves cells, no plasma/serum. #ASHG14
2:09pm October 19th 2014 via Hootsuite
AB: Crowd: disease samples, healthy cntls, RNA exp signatures. "The best tests are protein-based"; yet RNA isn't a great test #ASHG14
2:07pm October 19th 2014 via Hootsuite
AB: Every small molecule cmpd 'just sitting there awaiting for you to use it'. NIH LINCS program http://t.co/Jk7QeYqL2l #ASHG14
2:06pm October 19th 2014 via Hootsuite
AB: TCGA has 20K samples. On the drug side: PubChem http://t.co/BJP6wOgOf6 108M cpds, 650K assay, 1B datapts, 70T cells #ASHG14
2:05pm October 19th 2014 via Hootsuite
AB: NCBI GEO http://t.co/8FU14m5q3O and ArrrayExpress has >1M samples of data. 'This is retroactive crowdsourcing' 20K labs helping! #ASH
2:03pm October 19th 2014 via Hootsuite
AB: Holds up $AFFX GeneChip. 15y of data: White House policy http://t.co/oZSo1Ziuoe not only papers but also data #ASHG14
2:02pm October 19th 2014 via Hootsuite
AB: More than half of his graduate students have started companies, using open data #ASHG14
2:00pm October 19th 2014 via Hootsuite
Next: Atul Butte (Stanford) @atulbutte Crowd Experiments: Translating a trillion points of data into new disease insights #ASHG14
FK:Q:Apply to genotype/phenotype data modeling? A:Co-creator has Eterna for RNA, Phylo for seq alignment. But: get us thinking! #ASHG14
1:59pm October 19th 2014 via Hootsuite
FK:A2:'Black belts' show their tips on YouTube videos #ASHG14
1:57pm October 19th 2014 via Hootsuite
FK:Q:Many male players - has it changed? A:New survey; best players are female now ("Mimi" in UK) http://t.co/liDuXEwRwO #ASHG14
FK:A2:The gamer benefits from not knowing a lot about protein structure, to take a lot of risks. The monomer viral protein example #ASHG14
1:56pm October 19th 2014 via Hootsuite
FK:Q:Did Void_crusher get lucky? A:When Foldit players do well they do very well; when poor dramatic on opp direction. Taking risks #ASHG14
1:55pm October 19th 2014 via Hootsuite
FK:Future: add'l energy functions, incorp. exp. data into human protein modeling process. Maybe playing on an Xbox Kinect at home #ASHG14
1:54pm October 19th 2014 via Hootsuite
FK: (Names like Anthropomorphic_Dreams and Void_Crushers top of CASP10) #ASHG14
1:53pm October 19th 2014 via Hootsuite
FK:We fold picking out best Foldit prediction for CASP10, different alg than Rosetta. Top CASP10 were other Foldit teams #ASHG14
1:52pm October 19th 2014 via Hootsuite
FK:Teachers are assigning Foldit, kids love videogames, a great way for outreach. Now: http://t.co/xMYbLc38CP #ASHG14
1:51pm October 19th 2014 via Hootsuite
FK:And verified via crystal structure, to the 'experts' surprise. #ASHG14
1:49pm October 19th 2014 via Hootsuite
FK:What about design? Diels-Alder design, can you cover the ligand from a starting scaffold? Inserted 13 residues, 24aa loop #ASHG14
