Bianchi: 2104 ref that describes DFLAT: http://t.co/ws1pDuDvRB Now desc. oxidative stress in T21 fetus: mitochondrial disfunction #NICHD
9:39am January 21st 2015 via Hootsuite
Bianchi: In T21 311 genes were diff exp; 1/3 down-regulated. Credits @NIH and #NICHD for support of a new tool DFLAT http://t.co/9R7HS5LFmH
9:37am January 21st 2015 via Hootsuite
Bianchi:In T21: consistent pattern. '09 PNAS: http://t.co/DPAgYzYiIk Genes were not on Chr21 - it is from genome disregulation #NICHD
9:36am January 21st 2015 via Hootsuite
Bianchi:Connectivity map from @broadinstitute dev for cancer; desc in 07 paper: http://t.co/WU3jjMWwSE #NICHD
9:35am January 21st 2015 via Hootsuite
Bianchi:Most fetal gene exp. is done post-mortem. Here: first time in living fetus from AF. Comparing transcriptomes across T21, T18 #NICHD
9:33am January 21st 2015 via Hootsuite
Bianchi:Char 23 organ-specific genes in AF core transcriptome. Possibly: during open neural tube formation. Majority from brain #NICHD
9:32am January 21st 2015 via Hootsuite
Bianchi:From GNF Novartis Gene Exp Atlas: showed GAPDH consistency across tissues; lung-spec gene SFTB signal in lung & fetal lung #NICH
Bianchi:Retrospective study from 6: Hui et al http://t.co/RIcYCcTjpB Used @ingenuity pathway analysis, @affymetrix U133A arrays #NICHD
9:31am January 21st 2015 via Hootsuite
Bianchi:cfRNA & cfDNA, of normal/ab AF, 2014 pub http://t.co/6cl0Xn6Lq4 why microarray? Connectivity map usefulness #NICHD
9:29am January 21st 2015 via Hootsuite
Bianchi:Rec. drugs for a mouse model and then (hopefully) bring it back to the pt. Amniotic fluid: pure source of fetal nucl. acid #NICHD
9:28am January 21st 2015 via Hootsuite
Bianchi:The next frontier: fetal individualized medicine. Fetal gene exp. via microarray, use connectivity map to rec. drugs #NICHD
9:26am January 21st 2015 via Hootsuite
Bianchi: NIPT now: for high-risk, clin. trials, prof. society guidelines, insurance paid. PPV is lower for low-risk pregnancies #NICHD
9:25am January 21st 2015 via Hootsuite
Bianchi:FP/FN in Boston Globe article Dec 14 http://t.co/glDa3azTcu It's a screen, not a test. FP about 0.1% #NICHD
9:24am January 21st 2015 via Hootsuite
Bianchi:Changes their counseling - a broader spectrum sex aneuploidy. Y-chr. in fetal (from kidney transplant!). Now maternal cancer #NICHD
9:23am January 21st 2015 via Hootsuite
Bianchi: Her analysis reported in Clin Chem http://t.co/crrNM3Jn8m FP for sex char: mother's sex-chr. mosaicism 9% of the time #NICHD
9:22am January 21st 2015 via Hootsuite
Bianchi:Impact: dramatic. Rev of billing records show this, 2014 publ. http://t.co/hC9kVbwstW #NICHD
9:20am January 21st 2015 via Hootsuite
Bianchi:When NIPT is neg. - so close to 100%, no invasive testing. If pos. - need confirmatory testing. Low-risk: offered at Tufts #NICHD
9:19am January 21st 2015 via Hootsuite
Bianchi:In '11:T21, T18, T13: meta-analysis here, Gil et al http://t.co/l0FnMYsLds Very high accuracy detailed there #NICHD
9:18am January 21st 2015 via Hootsuite
Bianchi:cfDNA in maternal plasma comes from placenta, not the fetus; detectable in anembryonic gestations, before circ. established #NICHD
9:16am January 21st 2015 via Hootsuite
Bianchi:Showed inflection of NGS in '08; revolutionary concept of use as a tag-counting device. Reviewed cfDNA sequencing/mapping #NICHD
9:14am January 21st 2015 via Hootsuite
Bianchi:NIFTY should have been TM'd; now done by BGI (China) 4K samples to-date. Issue: how industry 'has run w/the ball' #NICHD
9:13am January 21st 2015 via Hootsuite
Bianchi:NIFTY: '94-'04, too few intact fetal cells for reliable analysis; higher # fetal cells in aneuploids; PCR better than FISH #NICHD
9:12am January 21st 2015 via Hootsuite
Bianchi:Two outcomes, termination or preparation; 'you cannot underestimate the value of this info. for preparation' #NICHD
9:11am January 21st 2015 via Hootsuite
Bianchi:Illustrates w/ ACOG Practice Bulletin; stds of care for fetal chr. abnormalities. #NICHD
Bianchi:NIFTY trial, feto-maternal DNA/RNA trafficking ('03-'14), others. 2 parts: changing paradigm from NGS, then transcriptomics #NICHD
9:09am January 21st 2015 via Hootsuite
Bianchi:Began w/ early flow cytometer for pre-natal Dx. What's the ROI of an R01? '85-'90 support: Flow-based mol. gen. fetal cells #NICHD
9:08am January 21st 2015 via Hootsuite
At NIH: Dr Bianchi "Changing Paradigms: From Prenatal Genetic Diagnosis to Fetal Individualized Medicine" #NICHD http://t.co/K7wmOEFLgb
9:05am January 21st 2015 via Hootsuite
Transcriptional profiling at single cell levels reveals somatosensory neuron molecular diversity | eLife http://t.co/Is5rpgLJfL
8:10am January 21st 2015 via Hootsuite
.@rymcbr W/blogs being so SEO-friendly, it isn't surprising. Search doesn't differentiate, only evaluates quality of the link as reputable.
8:09am January 21st 2015 via Hootsuite in reply to
.@rymcbr IMHO the Edelman survey confounds several questions; people use search to discover new info sources in particular blogs. 1/2
8:07am January 21st 2015 via Hootsuite in reply to
Dragging scientific publishing into the 21st century Genome Biology http://t.co/pL8JkZVFr5
7:15am January 21st 2015 via Hootsuite
RT @SMToolsGo: Worst passwords of 2014 are just as awful as you can imagine via @CNET http://t.co/j8WVxfgBkn
6:55am January 21st 2015 via Hootsuite
.@rymcbr Not necessarily Google being trusted - rather alt sources of news. For more balanced view (found via Google) http://t.co/wxyS8wbZH5
5:47am January 21st 2015 via Hootsuite in reply to
How Social Has Transformed 3 Traditional Marketing Scenarios | Spredfast http://t.co/rJdGbiM7tm
5:20am January 21st 2015 via Hootsuite
RT @harrymccracken: You very rarely see this style of camcorder anymore. http://t.co/3EUsaamlge
4:55am January 21st 2015 via Hootsuite
RT @KevinADavies: "I want the country that... mapped the human genome to lead a new era of medicine "---Take that UK, France, Germany, Japa…
10:07pm January 20th 2015 via Twitter Web Client
This Week in PLOS | GenomeWeb http://t.co/JuGq6p5iDl
9:50pm January 20th 2015 via Hootsuite
RT @nytimes: They completed the hardest climb in the world. Explore the route they took: http://t.co/XVMiKOVWw9 http://t.co/WhZDmKE34z
8:40pm January 20th 2015 via Hootsuite
Epilepsy Research Benefits from #Crowdsourcing | NIH Director's Blog http://t.co/SMWTPT94wW
7:00pm January 20th 2015 via Hootsuite
RT @LifeTech: #PAGXXIII - Developing Virus-resistant & Herbicide-resistant Cassava for Africa - http://t.co/v1YyJFaO9w
6:15pm January 20th 2015 via Hootsuite
New Post: Developing Virus- and Herbicide-resistant Cassava for Africa | Behind the Bench http://t.co/H6mfwQPB4G #PAGXXIII
6:10pm January 20th 2015 via Hootsuite
Comparison Shows Life Tech's CastPCR Provides Equivalent Results to Therascreen for KRAS Detection | GenomeWeb http://t.co/ysyDzMt51B
5:10pm January 20th 2015 via Hootsuite
New Method Allows for Genome, Transcriptome Sequencing from Single Cell | GenomeWeb http://t.co/5um7ptZhfz
4:10pm January 20th 2015 via Hootsuite
Marylyn Ritchie on Geisinger's Biomedical & Translational Informatics Program | GenomeWeb http://t.co/W8vg79wT3E EHRs + WES from 20K
3:45pm January 20th 2015 via Hootsuite
RT @Spredfast: Join our @AMA_Marketing webinar with @LinkedIn and learn the value of real-time marketing. http://t.co/UdUgLKRtsN http://t.c…
3:39pm January 20th 2015 via Twitter Web Client
Analysis of Hundreds of Y-Chromosomal SNPs for High-Resolution Paternal Lineage Classification - PubMed http://t.co/sORbplBrV8 @iontorrent
2:40pm January 20th 2015 via Hootsuite
Eric Talmadge is the only Western reporter regularly in North Korea. Here’s what it’s like. - The Washington Post http://t.co/Owb9ombzyR
1:10pm January 20th 2015 via Hootsuite
MT @JChrisPires: Thanks @NoahFahlgren #pagxxiii stats - @pop_gen_JED & @DaleYuzuki on top! I'm #3 by retweet only : ) http://t.co/IaQSe9
11:10am January 20th 2015 via Hootsuite
Warning: online flipboard magazine MT @DavidKirkpatric: @techonomy Magazine http://t.co/ORIAcjKdmW
10:05am January 20th 2015 via Hootsuite
Solving C. dficile RT @clopezcorrea: Changing your #microbiome, Fecal transplants could save lives #Genomics http://t.co/C96pqW7fYH
9:10am January 20th 2015 via Hootsuite
