RT @theNCI: NCI's annual review of #cancer statistics is available. http://t.co/uVNsu71qW1 via @NCICancerStats http://t.co/REM2gtvAZX
10:40pm April 30th 2015 via Hootsuite
RT @NatureNews: Don't blame it all on the P-value - it's just the tip of the shoddy-statistics iceberg http://t.co/2strMHt8iP http://t.co/i…
9:25pm April 30th 2015 via Hootsuite
Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans |BMC Genetics http://t.co/HlbmaBXeKi
9:15pm April 30th 2015 via Hootsuite
RT @EurekAlertAAAS: The Pillars of Creation revealed in 3-D http://t.co/RuUgUvjSSf via @ESO @EurekAlertAAAS http://t.co/In8lW6HGtd
8:15pm April 30th 2015 via Hootsuite
.@OmicsOmicsBlog I thought you'd find the latest from G Church of interest!
8:08pm April 30th 2015 via Hootsuite in reply to DaleYuzuki
RT @Paul_Sonnier: Walled gardens in #BRCA genetic research, diagnostic data http://t.co/fnMivCp8J1 #Genetics http://t.co/FblTghQBQB
7:10pm April 30th 2015 via Hootsuite
GPOPSIM: a simulation tool for whole-genome genetic data | BMC Genetics http://t.co/bTGz1AbqkA
6:10pm April 30th 2015 via Hootsuite
Beijing Babies Born During Olympics Are Heavier | Al Jazeera America http://t.co/tPKTbFXSyg
5:10pm April 30th 2015 via Hootsuite
The Apple Watch is a Watch. — The Message — Medium http://t.co/T7zbQaCMrP
4:25pm April 30th 2015 via Hootsuite
The world's thinnest transistor is just three atoms thick | The Verge http://t.co/6ZoaG3PyOv
3:10pm April 30th 2015 via Hootsuite
RT @WvSchaik: @BioMickWatson bioinformatics was first coined by Paulien Hogeweg http://t.co/fK1Xko4mSW in 1970 http://t.co/dLsxHN8Zr0
2:30pm April 30th 2015 via Hootsuite
Windows 10 apps in HoloLens look amazing and completely ridiculous | The Verge http://t.co/sakRjM1eoz
1:30pm April 30th 2015 via Hootsuite
Personalized medicine: Time for one-person trials : Nature News http://t.co/1AME0dCVDl
12:01pm April 30th 2015 via Hootsuite
Latest from George Church: Evolution-guided optimization of biosynthetic pathways. PNAS - PubMed http://t.co/KWdfCiAWlO
11:50am April 30th 2015 via Hootsuite
RT @mathews_joel: Human-embryo editing poses challenges for journals http://t.co/sBa6D4kF7c
10:45am April 30th 2015 via Hootsuite in reply to mathews_joel
RT @Otto_English: Bravo. @guardian http://t.co/AXGBUxL950
9:30am April 30th 2015 via Hootsuite
RT @NatureNews: US funder reiterates research ban that involves gene-editing of human embryos http://t.co/7OekXBUip3 http://t.co/RLo3UbJtuS
8:50am April 30th 2015 via Hootsuite
As I'm a Sagittarius that's why I broke my arm. Spurious associations: astrological signs and health - PubMed http://t.co/5mtH9mlXgi
7:25am April 30th 2015 via Hootsuite
RT @AACR: Watch for free: Select #AACR15 webcasts are available now — http://t.co/JMUGB0490C http://t.co/00k56il70T
6:10am April 30th 2015 via Hootsuite
RT @ldtimmerman: Q&A With Jay Flatley, CEO of @Illumina. New on @Forbes http://t.co/Le7swnxm6k
5:40am April 30th 2015 via Hootsuite
The four global forces breaking all the trends | McKinsey & Company http://t.co/M2Bpra7Rlz 3,000x the impact of the Industrial Revolutio
4:20am April 30th 2015 via Hootsuite
The next generation of medical tools may be home-brewed — Medium http://t.co/Uji9wt9IVR
10:30pm April 29th 2015 via Hootsuite
RT @DesignUXUI: Most startups… http://t.co/eQZQlviMsJ
9:50pm April 29th 2015 via Hootsuite
RT @GenomeAtlantic: Wow! Genetic testing moves into world of employee health http://t.co/SvaYfvfSYi @SeattlePI @genomecanada
8:50pm April 29th 2015 via Hootsuite
RT @MishaAngrist: "What good is a miracle drug if you can’t afford it?” http://t.co/u5LXTWSFgV
7:50pm April 29th 2015 via Hootsuite
RT @dotMorten: Shut up and take my money #HoloLens
6:10pm April 29th 2015 via Hootsuite
.@sesiegler Nice to see Lipsett Auditorium (NIH campus) completely full for this great talk. Remarkable work.
5:20pm April 29th 2015 via Hootsuite in reply to sesiegler
SR: Conclude "ID and targeting of muts unique to each cancer has the potential to extend cell therapy to pts w/common epith cancers" #NIH
5:19pm April 29th 2015 via Hootsuite
SR: JCO '11 ref http://t.co/ELyy0UhMWT Several scans of pts receiving the ongoing regression for both primary & metastatic sites #NIH
5:18pm April 29th 2015 via Hootsuite
SR: One last target: Cancer-testes Ags, expressed during fetal dev. RT-PCRs, single-digit expression to 30% of multiple tumor types #NIH
5:16pm April 29th 2015 via Hootsuite
RT @halletecco: Apple makes ethics board approval mandatory for all medical research apps http://t.co/nQvYsRYAYS
5:15pm April 29th 2015 via Hootsuite in reply to halletecco
SR: Showed before & after 24w w/antiCD19 CART: disappearing liver mets. #NIH
5:14pm April 29th 2015 via Hootsuite
SR: First Pt anti-CD19 retroviral CAR: report '12 Blood ref http://t.co/VCCAd26WX5 But normal b-cells are gone. T-cells, NK cells OK #NIH
5:13pm April 29th 2015 via Hootsuite
SR: Chimeric antigen receptor (CAR), described. T-cell w/recognition of an Ab, but ability to kill. Targeting CD19 - scFv retrovirus #NIH
5:11pm April 29th 2015 via Hootsuite
SR: Categories of antigens to target: unique mutations to individ. cancer, or antigens expressed on non-essential normal tiss (CD19) #NIH
5:10pm April 29th 2015 via Hootsuite
SR:Lessons - T-cells can recognize 'as few as 5 molecules on the cell surface'. Thus minimal exp. on normal cells -> serious toxicity #NI
5:08pm April 29th 2015 via Hootsuite
SR: Examination of PD-1+ derived TIL, #'s of TCR clonotypes; add'l TCR data suggests feasibility of TCR transfection approach #NIH
5:07pm April 29th 2015 via Hootsuite
SR:'Ultimate personalized therapy.' Need to enrich TIL or PBL for mutation reactive cells; target 'driver' muts; engineer naive cells #NIH
4:59pm April 29th 2015 via Hootsuite
SR:18/20 of metastatic epithelial cancers express immunogenic mutations - and every one is unique. #NIH
4:58pm April 29th 2015 via Hootsuite
SR: Many non-specific tandem minigenes ("TMG") from others; one positive. Pt. seen today, after 2 mo 'dramatic regression' in lung mets #NIH
4:56pm April 29th 2015 via Hootsuite
SR: Showed evidence that the transfected TCR can impart protective effect in-vitro. Another Pt. showed specificity of his assay #NIH
4:55pm April 29th 2015 via Hootsuite
SR: 5 pts so far: are still exploring best methods. Shows TMG-2 reactive to CD8+ cells, TMG-5 to CD4+. GPD2 & CHD6 the 2 genes from pt #
4:53pm April 29th 2015 via Hootsuite
SR: T-cell receptor isolated; put into Pts' lymphocytes. Important way forward to apply this - can provide TCRs into naive memory cells #NIH
4:50pm April 29th 2015 via Hootsuite
SR: One culture had high concentration of cells reactive to ERBB2IP Success story. Tran ref Science '14 http://t.co/Me7PyATbLz #NIH
4:49pm April 29th 2015 via Hootsuite
SR: Ox-40 up-reg - perhaps CD4+ presentation. ID'd one mutation in minigene 1 by 2 assays; gene was ERB2IP, tumor supp binds to ERBB2 #NIH
4:48pm April 29th 2015 via Hootsuite
SR: Lung met had 26 nsSNVs. So made 3 tandem minigenes. In-vitro translated protein, transfect into APC, present to TILs in culture #NIH
4:47pm April 29th 2015 via Hootsuite
SR: Pt MB: metastatic cholangiocarcinoma. Lots of chemo. TIL infused, minimal response. Tandem minigene tried #NIH
4:46pm April 29th 2015 via Hootsuite
SR: Can this approach be used to treat common epithelial cancers? Concentrated on GI, Pancreatic cancers #NIH
4:45pm April 29th 2015 via Hootsuite
SR: These mutations are likely targets of IL-2, anti-CTLA4, and anti-PD1 as well. #NIH
4:44pm April 29th 2015 via Hootsuite
SR: So far: never found a duplicate antigen recognized by the T-cell. 'Apparently random mutation' - unexpected finding. #NIH
