Throughout cancer's history - a guarded optimism. Reluctant to use 'cure', but 'just a matter of time it will become manageable #CancerFilm
10:51pm April 1st 2015 via Twitter Web Client
Baselga: This immune response is different; the cancer doesn't come back. #CancerFilm
10:49pm April 1st 2015 via Twitter Web Client
"Two years cancer-free is a great day" #CancerFilm
10:47pm April 1st 2015 via Twitter Web Client
"(Emily) is absolutely a pioneer... she taught us about toxicity control" 27/30 more children have had complete responses #CancerFilm
'We'll continue monitoring (Emily's) condition' - 'we're super-excited we're at this point' - uncharted territory #CancerFilm
10:46pm April 1st 2015 via Twitter Web Client
Emily 2y after treatment - returns for a check-up. Mom: 'Always a little nervous' Dr. "Any problems?" "No" #CancerFilm
10:45pm April 1st 2015 via Twitter Web Client
Doug Rogers a month after infusion: 'it looks so much better. It feels better' A 55% decrease. Marked decrease in size (visible) #CancerFilm
10:43pm April 1st 2015 via Twitter Web Client
Rosenberg's trial: 18/25 saw shrink, 9 alive after 5y. But nothing more to offer. 'This is a life & death visit for these pts' #CancerFi
10:42pm April 1st 2015 via Twitter Web Client
Now beginning to see the immune system being educated; 'something of a roulette wheel'; why some effective, and not others? #CancerFilm
10:41pm April 1st 2015 via Twitter Web Client
After Emily - dozens more, now photos of her growing up. Uncharted territory - how long her immune cells would work. #CancerFilm
10:40pm April 1st 2015 via Twitter Web Client
'Her response was astonishing' Never had seen anyone that sick, get better. Emily woke up 7d later. 3w later: cancer free. #CancerFilm
10:39pm April 1st 2015 via Twitter Web Client
Emily 'can't be any sicker... so now what?' Frantic - tested, found IL-6 skyrocketing. Tried IL-6 antagonist (never tried)#CancerFilm
10:38pm April 1st 2015 via Twitter Web Client
'And when they were done there were 17 IV pumps keeping her alive' Mom: "this can't be the end" #CancerFilm
10:37pm April 1st 2015 via Twitter Web Client
Emily's dad - 'a few days later she was riding on my back' 'and then things spun out of control' 'and they put her to sleep' #CancerFilm
Rogers: "I feel my cells getting to work, like PacMan getting those melanoma cells" #CancerFilm
10:36pm April 1st 2015 via Twitter Web Client
Doug Rogers gets the infusion from a smaller reserve batch. 'The first time Rosenberg has had to do this.' #CancerFilm
10:35pm April 1st 2015 via Twitter Web Client
'How effective this will be in kids - only known by doing it." (So hard to see Emily.) #CancerFilm
10:34pm April 1st 2015 via Twitter Web Client
Emily at CHOP (Philadelphia) - the 4th person, the 1st child: her own engineered T-cells given back to her. #CancerFilm
Problem - a virus infected his cells, can't use them. New batch to prepare in the next week for infusion later #CancerFilm
10:33pm April 1st 2015 via Twitter Web Client
Back at Rosenberg's lab - over 1B cells given back, he looks at his own cells before transfusion. He handles T-175 flask #CancerFilm
10:31pm April 1st 2015 via Twitter Web Client
Enrolled in new trial - 'if it didn't work we only probably had a few weeks with her'. #CancerFilm
10:30pm April 1st 2015 via Twitter Web Client
Clinical trial in leukemia pts. 6yo girl Emily: full relapse, <30% survival. Mother: "Very few survived w/that mutation." #CancerFilm
10:29pm April 1st 2015 via Twitter Web Client
But a novel approach may expand it: genetically engineer immune cells. Redirecting T-cells to home into cancer. UPenn work #CancerFilm
10:28pm April 1st 2015 via Twitter Web Client
Exciting about these drugs, unlike Rosenberg's, could be given at any cancer clinic. Mainly effective for melanoma & kidney #CancerFilm
10:27pm April 1st 2015 via Twitter Web Client
'96 Allison developed a compound; Yervoy came to market. And several other drugs along the same principle to follow #CancerFilm
10:26pm April 1st 2015 via Twitter Web Client
Early 80's - Allison at MD Anderson told 'it would stall his career'. His idea - not stimulated, but removing restraints #CancerFilm
10:24pm April 1st 2015 via Twitter Web Client
A mole on a patient's leg, too over the body. Isolated immune cells from a removed tumor. Dissected, put into culture, 4 weeks #CancerFilm
10:23pm April 1st 2015 via Twitter Web Client
'Most of whom have exhausted every other treatment'. (Note - melanoma is a tough, tough disease.) #CancerFilm
10:20pm April 1st 2015 via Twitter Web Client
Cancer-fighting T-cells taken out, strengthened, and given back to the same patient. Several melanoma clinical trials #CancerFilm
Rosenberg: "In a tiny percentage of patients, the cancer disappeared" Immune cells educated to attack the cancer #CancerFilm
10:19pm April 1st 2015 via Twitter Web Client
Rosenberg: Isolated various types, and progress 'painfully slow', first 66 patients no progress. But 67th: 30y later still well #CancerFilm
10:18pm April 1st 2015 via Twitter Web Client
RT @theNCI: NCI's Dr. Steven Rosenberg studies immunotherapy for advanced cancers: http://t.co/tuJaUeg3CD #CancerFilm #ImmunoOnc http://t.c…
Steven Rosenberg's effort on immune cells, I blogged about it here: http://t.co/af2vpieKPw #Cancerfilm
10:17pm April 1st 2015 via Twitter Web Client
Coley's could not be replicated, and fell out of favor. Immunotherapy 'remained a backwater, but a few kept the field alive" #CancerFilm
10:16pm April 1st 2015 via Twitter Web Client
And that weapon - the human immune system. Wiliam Coley - early 20th century, a compound of infectious bacteria. Some cured. #CancerFilm
10:15pm April 1st 2015 via Twitter Web Client
"Imagine capturing billions of years of evolution in a single cell" That's cancer - a billion times the speed of evolution #CancerFilm
10:13pm April 1st 2015 via Twitter Web Client
But combination therapies still must battle cancer's complexity. "Think of cancer as 'evolution in a bottle'" #CancerFilm
Cost of sequencing plummet - possible to personalize a combination of drugs. "Just like an infection." #CancerFilm
10:12pm April 1st 2015 via Twitter Web Client
Vogelstein "200 genes funnel down into about 12 pathways" A pathway: like a 'bucket brigade' (Golub) Multiple places to disrupt #CancerFilm
10:11pm April 1st 2015 via Twitter Web Client
Again multi-drug therapies - catalog mutations, and find vulnerabilities. (Lander) 'A way to deploy your armies' #CancerFilm
10:10pm April 1st 2015 via Twitter Web Client
RT @aicrtweets: Obesity increases risk for 10 cancers, our infographic.http://t.co/w3xV44yoWt #cancerfilm http://t.co/cPitEQRJaH
10:09pm April 1st 2015 via Twitter Web Client
Trend of patterns within the cancer cell - not all mutations equally significant. Most are random. Just a few key ones (Lander) #CancerFilm
10:08pm April 1st 2015 via Twitter Web Client
With BRCA mutation - 70% br ca, 30% ovarian. Collins: family history, environmental, and DNA. Prevention on the individ. #CancerFilm
10:07pm April 1st 2015 via Twitter Web Client
Mary Claire King - discovered hereditary breast cancer gene BRCA1/2 by looking at familial breast cancer (mastectomy study) #CancerFilm
10:05pm April 1st 2015 via Twitter Web Client
Markers can be in the form of mutations. Fun seeing an autogradiogram of DNA sequence being read out. Nostalgia! #CancerFilm
10:03pm April 1st 2015 via Twitter Web Client
Men not spared either, with the PSA test and its false-positives. Bishop: consequences of being wrong 'devastating' #CancerFilm
10:02pm April 1st 2015 via Twitter Web Client
Mammogram false positives result in disfiguring, needless surgery. 'Ethically and economically difficult to stop' #CancerFilm
10:01pm April 1st 2015 via Twitter Web Client
At MD Anderson - the mammogram hailed as a breakthrough, the test becomes part of an annual checkup. But controversial #CancerFilm
10:00pm April 1st 2015 via Twitter Web Client
And early prevention another tool; cure via surgery. Colon cancer screening popularized; colon ca down 10% #CancerFilm
9:59pm April 1st 2015 via Twitter Web Client
Vogelstein: "Cancer rates can be reduced 50% if we simply implement all we already know about prevention" #CancerFilm
9:58pm April 1st 2015 via Twitter Web Client
