May 2015

Breen:Q:Do sea lions get other cancers? A:Yes, but focus on urogenital as they are exposed to environmental conditions as sentinels #ASCO15

7:06pm May 30th 2015 via Hootsuite

Breen: Developed an NCI 'Canine Comparative Oncology and Genomics Consortium' http://t.co/3nA6CULxK4 #ASCO15

7:02pm May 30th 2015 via Hootsuite

Breen: Looking at urogenital carcinoma in a third spp - sea lion. Showed a photo of sea lion affected organ. Same genetic aberration #ASCO15

7:01pm May 30th 2015 via Hootsuite

Breen: Dog urothelial carcinoma '15 ref http://t.co/zqsVlCQrnI #ASCO15

7:00pm May 30th 2015 via Hootsuite

Breen: Can genes in the dog ID new opportunities in human? Canine bladder ca - looked at aCGH for CNV. 13/19/36 aneuploidy #ASCO15

6:58pm May 30th 2015 via Hootsuite

Breen:One example: chr 9-22 translocation and Gleevec.CML very rare, but was found in dogs. FISH shown. Tyr kinase inh worked #ASCO15

6:55pm May 30th 2015 via Hootsuite

Breen: Until 10y ago, no reagents. Started with canine genome seq. Many different options for analysis; here only chr aberrations #ASCO15

6:53pm May 30th 2015 via Hootsuite

Breen: Highlights Golden Retrievers, and Burnese Mt dogs - naturally occurring, recurrent cancers. 'Powerful opportunity' w/drivers #ASCO15

6:51pm May 30th 2015 via Hootsuite

Breen:78% of purebred dogs are only 30 breeds. Purebreds are highly constrained in variation. #ASCO15

6:50pm May 30th 2015 via Hootsuite

Breen: "Rover is the offspring of a mating between his father and father's mother. Rover's mother is also his aunt and half sister" #ASCO15

6:48pm May 30th 2015 via Hootsuite

Breen: 15k of intensive breeding - human 4 gen pedigree. For a dog: effect of inbreeding shown in pedigrees #ASCO15

6:47pm May 30th 2015 via Hootsuite

Breen: Pet dogs get spontaneous cancers, similar genomes, and share our environment. Highly comparable models of cancer #ASCO15

6:43pm May 30th 2015 via Hootsuite

Breen:Dogs: 83M pet dogs in US in 57M households. 55% are purebred. 10% of 42M vet visits are for cancer. 25% of all dogs get cancer #ASCO15

6:42pm May 30th 2015 via Hootsuite

Breen: Comparative genomics: the mouse a workhorse. But mice don't get spontaneous cancer. Many other animals do though. #ASCO15

6:40pm May 30th 2015 via Hootsuite

Breen: Going back to Virchow: "betw. animal and human medicine there is no dividing line - nor should there be" #ASCO15

6:39pm May 30th 2015 via Hootsuite

Matthew Breen (North Carolina State Univ) "Comparative Oncology: What Can Dogs and Sea Lions Teach Us about Cancer?" #ASCO15

6:38pm May 30th 2015 via Hootsuite

Maley: Dispersal theory suggests micromets are selected for motility, constructing favorable niches #ASCO15

6:31pm May 30th 2015 via Hootsuite

Maley: Comp. for resources; spatial and temporal heterogeneity. Neoplastic cells evolve motility '12 ref http://t.co/3yYwZkcKdk #ASCO15

6:26pm May 30th 2015 via Hootsuite

Maley: Poor prognosis: large populations, genetic diversity, wide dispersal, motility, generalism (adapted to different environment) #ASCO15

6:24pm May 30th 2015 via Hootsuite

Maley:Lessons - disrupt habitat (microenvironment); target multiple pathways; maintain selective pressures for many generations #ASCO15

6:22pm May 30th 2015 via Hootsuite

Maley: Looked at paleontology for mass extinction events analogous to cancer. '15 ref http://t.co/8tRVYVi9i2 #ASCO15

6:21pm May 30th 2015 via Hootsuite

Maley: '12 NEJM ref http://t.co/mv4HcVmB8m May need to look at combination therapy, lower dose therapy, adaptive therapy #ASCO15

6:18pm May 30th 2015 via Hootsuite

Maley: Shows illus from 2011 Ding clonal expansion; almost all resistance mutations already present prior to treatment #ASCO15

6:16pm May 30th 2015 via Hootsuite

Maley: 'Every tumor is snowflake on steroids'. 100's of thousands of alterations. Mutation rate 10^1 - 10^5 / generation #ASCO15

6:14pm May 30th 2015 via Hootsuite

Maley: Tumor evolution by natural selection; every hallmark either increases reproduction or survival #ASCO15

6:12pm May 30th 2015 via Hootsuite

Carlo Maley (Univ CA San Francisco) "Clonal Evolution in Metastasis: How Can Darwin Improve Cancer Outcome?" #ASCO15

6:10pm May 30th 2015 via Hootsuite

Nunney: 'Cancer persists b/c natural selection has limits on how effective it can be'. #ASCO15

6:02pm May 30th 2015 via Hootsuite

Nunney: Risk increases linearly w/body size; risk inc. as power function w/lifespan; risk inc. as power function w/somatic mutation #ASCO15

5:59pm May 30th 2015 via Hootsuite

Nunney: But the naked mole rat '14 Nature Rev Genet ref http://t.co/Oz9ydtsgQo unique mechanisms for longevity #ASCO15

5:55pm May 30th 2015 via Hootsuite

Nunney:Resolving the paradox: cancer suppression is an evolving trait.Telomerase and size of diverse animals http://t.co/cbS2f5KHQA #ASCO15

5:54pm May 30th 2015 via Hootsuite

Nunney: '11 Green ref http://t.co/pDy5X6EOt3 height as a proxy for cell number. http://t.co/4GVvEDaGA8 #ASCO15

5:51pm May 30th 2015 via Hootsuite

Nunney: Multistage carcinogenesis: we're bigger, live longer than mice. Called Peto's Paradox. Are size and longevity risk factors? #ASCO15

5:49pm May 30th 2015 via Hootsuite

Nunney: Armitage and Doll in 1954: hypothesized 6 or 7 hits. Knudson (1971) proposed 2-hit model for Rb. What number is it? ASCO15

5:48pm May 30th 2015 via Hootsuite

Leonard Nunney (UC Riverside) "Evolutionary Context of Cancer: Why Do People Get Cancer?" #ASCO15

5:46pm May 30th 2015 via Hootsuite

Shlush: Recent Science ref http://t.co/VKYKQ1zAy8 of normal skin mutations #ASCO15

4:58pm May 30th 2015 via Hootsuite

Shlush: WGS exposes high freq of pre-malignant mutations in functional cells. Evidence from Hiroshima radiation-related ca: 10y #ASCO15

4:57pm May 30th 2015 via Hootsuite

Shlush: '14 NEJM http://t.co/tImP8U4fDq clonal hematopoiesis evident as system ages. 'if we live long enough we'll all get leukemia' #ASCO15

4:55pm May 30th 2015 via Hootsuite

Shlush: Looked at 900 healthy individ's - 1:60 carrier rate for DNMT3a mutation. Pre-malignant mutations are freq in human pop #ASCO15

4:53pm May 30th 2015 via Hootsuite

Shlush: DNMT3a in pre-leukemic stem cells in AML '14 Nature ref http://t.co/4RBHhLehRl Found in 11/11 pts; 50% of stem cells #ASCO15

4:52pm May 30th 2015 via Hootsuite

Shlush: Starts with description from '12 Nature ref http://t.co/qTsR4apC15 pre-malignant selective pressures different than malig #ASCO15

4:45pm May 30th 2015 via Hootsuite

Liran Shlush (Princess Margaret Cancer Centre) "Clonal Evolution Models of Tumor Heterogeneity" #ASCO15

4:43pm May 30th 2015 via Hootsuite

Swanton: Mutational burden and PD-1 blockage shown to be promising. '15 Science ref http://t.co/S5q9Am1mO8 #ASCO15

4:43pm May 30th 2015 via Hootsuite

Swanton: Refers to the Bettegowda '15 ref http://t.co/x2BxsJGapY of ctDNA #ASCO15

4:39pm May 30th 2015 via Hootsuite

Swanton: Description of case here '15 Favero ref http://t.co/XC9Surn2Ru double-minute chromosome #ASCO15

4:37pm May 30th 2015 via Hootsuite

Swanton: Low freq events at diagnosis can influence outcome (recurrance or resistance). Case of G2 astrocytoma, G4 glioblastoma #ASCO15

4:36pm May 30th 2015 via Hootsuite

Swanton: Treatment in glioma, creates huge diversity '14 Science ref http://t.co/4dH1iap0s7 resulting in aggressive recurrance #ASCO15

4:34pm May 30th 2015 via Hootsuite

Swanton: Recent '15 review http://t.co/AHqILXsKXG The order of tumor events may matter #ASCO15

4:32pm May 30th 2015 via Hootsuite

Swanton: Emerging that subclonal driver mutations have poorer outcomes. Fig from '13 ref http://t.co/01t477o2e3 #ASCO15

4:30pm May 30th 2015 via Hootsuite