I’m a high-risk pregnancy expert. So why didn’t I worry about my own fertility? - The Washington Post https://t.co/lwHCwZ0pr4
6:10pm February 26th 2016 via Hootsuite
Science Fairs Have Lost Their Way. Let’s Make Them Cool Again | WIRED https://t.co/QXbrwwyIIa
5:45pm February 26th 2016 via Hootsuite
Intel hops on the precision medicine bandwagon with new projects for 2016 - FierceMedicalDevices https://t.co/DwYx4pUm0d
5:22pm February 26th 2016 via Hootsuite
RT @NatureNews: What are your tech predictions for #futuregenerations? https://t.co/66Ankw9UrE https://t.co/6QTcQYcPrg
4:10pm February 26th 2016 via Hootsuite
Understanding the links between privacy and public data sharing. - PubMed https://t.co/OurX6HG8LC
1:50pm February 26th 2016 via Hootsuite
RT @NatureNews: Fight brews over promising 'nanopore' genetic-sequencing technology https://t.co/b8bFHGuJ7u https://t.co/xsLbYbkPjQ
12:10pm February 26th 2016 via Hootsuite
RT @ACGT_blog: New post: How would you describe genomics without using any scientific jargon? https://t.co/NRkBALzVjV
11:30am February 26th 2016 via Hootsuite
CoreGenomics: Longitudinal monitoring of tumour burden with a modified Guthrie card https://t.co/TEjKYqlzOf
10:50am February 26th 2016 via Hootsuite
First PrecisionFDA Challenge Seeks Pipelines for Variant Call Comparisons | GenomeWeb https://t.co/hg69vQhesZ
9:55am February 26th 2016 via Hootsuite
Bio-Rad Q4 Revenues Fall 5 Percent; Firm Gets CE IVD Mark for Droplet Digital PCR System | GenomeWeb https://t.co/lMxLpss5nR
8:55am February 26th 2016 via Hootsuite
Genomic analyses identify molecular subtypes of pancreatic cancer. - PubMed https://t.co/gJ5Khni01Q
7:10am February 26th 2016 via Hootsuite
White House Announces Efforts to Accelerate Precision Medicine Initiative | GenomeWeb https://t.co/gyYlCuNtxl
6:35am February 26th 2016 via Hootsuite
Feb 26 Friday noon ET / 5 GMT NGS Oncology Panels and the FDA Webinar | TOMABio @SeraCare https://t.co/EQuOFh5TFt
5:20am February 26th 2016 via Hootsuite
Opening a window of opportunity for head and neck cancer — Medium https://t.co/6q9Jb0zPsV
10:35pm February 25th 2016 via Hootsuite
The Step-By-Step Guide To Getting Famous On Social Media — Medium https://t.co/4W691Ehtvx
9:35pm February 25th 2016 via Hootsuite
This is the least useful passport to carry around the world - The Washington Post https://t.co/Qwd9zgCi9S
9:30pm February 25th 2016 via Hootsuite
Alipay is 73% of China's mobile transactions. How Mobile Payments Reshape Lifestyles - WSJ https://t.co/G4smL1nz0V
8:05pm February 25th 2016 via Hootsuite
Verily tapped by NIH to launch Obama's Precision Medicine Initiative - FierceMedicalDevices https://t.co/vRWVWj9VEH
6:40pm February 25th 2016 via Hootsuite
RT @DaleYuzuki: Register for Friday's noon ET / 5 GMT NGS Oncology Panels and the FDA Webinar | TOMABio @SeraCare https://t.co/EQuOFh5TFt
4:05pm February 25th 2016 via Hootsuite
RT @kennamshaw: Roger Klein from #AMP, I think you are amazing! his public statement is a must! pushing #FDA to limit role to instrument an…
4:03pm February 25th 2016 via Twitter Web Client
Garlick: Binomial distribution: expect a 6% outliers, some low, others high (10% and 21%). Controls need to have flexiblilty #FDANGSWorkshop
4:02pm February 25th 2016 via Twitter Web Client
Garlick: 10% chart; looks like Ion Torrent has +2% AF at 10% and 20% compared to Illumina #FDANGSWorkshop
4:00pm February 25th 2016 via Twitter Web Client
Garlick:Background is PGP GM24385, measured value 18% and 10.3% by platform (ILMN or Ion Torrent). 1200 datapts/plot #FDANGSWorkshop
Garlick: Ability to trend data, challenge LOD, can test this. Did an inter-laboratory study, 4 SNVs, 4 indels, 18 SNVs #FDANGSWorkshop
3:59pm February 25th 2016 via Twitter Web Client
Russell Garlick (SeraCare Life Sciences) Doing QC standards, reference materials. Pt samples is the internal ctrl #FDANGSWorkshop
3:57pm February 25th 2016 via Twitter Web Client
Klein: Interpretation is a considerable medical judgement #FDANGSWorkshop
3:56pm February 25th 2016 via Twitter Web Client
Klein: Intrinsic properties of the smpl- CNV, aneuploidy. Complex variables require 'considerable medical judgement' #FDANGSWorkshop
Klein: An 'obsolete CDx approach'. Should be the job of the clinician. Professional, medical practice. Mfrs accurate calling #FDANGSWorkshop
3:55pm February 25th 2016 via Twitter Web Client
Klein:Instruments, reagents, informatics should be the focus, a representative sample of matrices and variants #FDANGSWorkshop
3:54pm February 25th 2016 via Twitter Web Client
Roger Klein (AMP) Sees the need for 'more appropriate regulatory pathways. FDA's approach to CDx may not be compatible w/NGS #FDANGSWorkshop
3:53pm February 25th 2016 via Twitter Web Client
Sninsky: Also recommended cloud-based analysis for community evaluation. Concordance between bioinf pipelines #FDANGSWorkshop
3:51pm February 25th 2016 via Twitter Web Client
Sninsky: Clinical-grade and research-grade NGS tests are different. High-quality databases (like CFTR) needed #FDANGSWorkshop
3:50pm February 25th 2016 via Twitter Web Client
Sninsky: cfDNA monitoring test for donated organ injury. List of rec's: select representative var's, w/boundary properties. #FDANGSWorkshop
3:49pm February 25th 2016 via Twitter Web Client
Sninsky: Serve 2.5K heart xplants/year. AlloMap product aids ID stable allograft fn. FDA cleared test #FDANGSWorkshop
3:48pm February 25th 2016 via Twitter Web Client
John Sninsky (CareDx): Organ transplant at higher risk for de novo cancer risk, higher than general population #FDANGSWorkshop
3:47pm February 25th 2016 via Twitter Web Client
Willey: Opt conditions: 50K copies, 1K amplicons sequenced; LOD 0.4% assuming 200 mut copies, 50K WT copies, 1000x depth #FDANGSWorkshop
3:46pm February 25th 2016 via Twitter Web Client
Willey: Shows sequencing depth and CV measurement dependency; 'CV should be estimated for each var fraction' #FDANGSWorkshop
3:44pm February 25th 2016 via Twitter Web Client
Willey: Shows data between error rate of native and 'internal standard', sees nice alignment #FDANGSWorkshop
3:43pm February 25th 2016 via Twitter Web Client
Willey: Determination of confidence; 'inadequate loading at each step indep increases measurement imprecision' #FDANGSWorkshop
3:42pm February 25th 2016 via Twitter Web Client
James Willey (Univ Toledo) Using synthetic controls - 3 perf characteristics '15 ref https://t.co/yUCyNunhVP #FDANGSWorkshop
3:41pm February 25th 2016 via Twitter Web Client
Aisner: No such thing as 'sample-in, answer-out' type system. Professional involvement needed #FDANGSWorkshop
3:35pm February 25th 2016 via Twitter Web Client
Aisner: An EGFR example with qPCR: where signal at Ct 34, out of range, pt is responding to Rx #FDANGSWorkshop
Aisner: Beware that the test is not more impt than the biology. #FDANGSWorkshop
3:34pm February 25th 2016 via Twitter Web Client
Open comment session: Dara Aisner (U CO): Need for ongoing QC, need to have flexibility to 'act upon ID'd weaknesses' #FDANGSWorkshop
3:33pm February 25th 2016 via Twitter Web Client
Dickson: Pts may prefer more sens over specificity; clinicians will collect the data, and better understand #FDANGSWorkshop
3:02pm February 25th 2016 via Twitter Web Client
Dickson: NGS w/more sens - many more pts will respond. Pt 'clinical FP': won't respond for any reason - will worsen #FDANGSWorkshop
Q:(Yve K from SeraCare) KRAS and CDx of 2 tests; 1-5% But NGS may be 5%. It says 'Qualitative' via the FDA #FDANGSWorkshop
3:01pm February 25th 2016 via Twitter Web Client
Kruez: "Do it upfront, and do it all" (i.e. testing). But extensive tests takes add'l time. #FDANGSWorkshop
2:58pm February 25th 2016 via Twitter Web Client
Sklar: Larger panels may have a use for validation purposes (pathways) so validation doesn't have to happen twice #FDANGSWorkshop
2:57pm February 25th 2016 via Twitter Web Client
Kulkarni: Can find driver mutations in normal individuals. Vendors need to use a lot of caution #FDANGSWorkshop
2:55pm February 25th 2016 via Twitter Web Client
