Alix-Panabieres: CTC line as xenografts cp w/primary tumor, shows BRAF V600E and KRAS Wt reproducibility #MDxE16
4:44am April 5th 2016 via Hootsuite
Alix-Panabieres: Using Elispot assay, CK19, FGF2, VEGF levels. Functional analysis shows in vitro tube formation frm supernate #MDxE16
Alix-Panabieres: Cp single cells to clusters cultures, CNV analysis comparable; shows RNA level cp among specific markers #MDxE16
4:42am April 5th 2016 via Hootsuite
Alix-Panabieres: Her work '15 Cancer Res for colon ca https://t.co/W0yxLRocl7 Key was negative selection. Shows plasticity. #MDxE16
4:41am April 5th 2016 via Hootsuite
Alix-Panabieres: CTC expansiin - '13 Nature Biotech https://t.co/oRYUqiSofk other papers cultured for weeks #MDxE16
4:39am April 5th 2016 via Hootsuite
Alix-Panabieres: Tried to capture ex-vivo for many years; DNA/RNA/Protein level; which is the real culprit given heterogeneity? #MDxE16
4:37am April 5th 2016 via Hootsuite
Catherine Alix-Panabieres (Univ Montpellier): Detection, characterization, and ex-vivo expansion of viable circulating tumor cells #MDxE16
4:36am April 5th 2016 via Hootsuite
Pantel:A2: Something wrong about these demands; how many images taken? Insistence on a 'perfect marker' may be the problem #MDxE16
Q: Why so long to get clin adoption? Pantel: ~20K biomarker papers/y. How many make it to clinic? Biomarker demands: need 'perfect' #MDxE16
4:35am April 5th 2016 via Hootsuite
Q: Cp of primary vs metastatic CTCs to det primary origin? Pantel: Early data is going in the right direction #MDxE16
4:33am April 5th 2016 via Hootsuite
Pantel: CANCER-ID EU consortium started 2015-2020. https://t.co/KL1kLXh8A7 #MDxE16
4:31am April 5th 2016 via Hootsuite
Pantel: Screening, real-time monitoring; risk for met relapse; Rx targets and resistance mechanisms; effect on clinical practice #MDxE16
4:30am April 5th 2016 via Hootsuite
Pantel: Progressive disease from no chemo treatment in br ca: CTCs not restricted to dying cancer cells. #MDxE16
4:29am April 5th 2016 via Hootsuite
Pantel: CTCs vs ctDNA: CTCs have RNA, protein, but 'both are complementary'. Impact may be time-dependent. Assaying the 'survivors' #MDxE16
4:28am April 5th 2016 via Hootsuite
Pantel: Their use is a 'simple Eppendorf device' as well as Silicon Biosystems DEPArray. #MDxE16
4:27am April 5th 2016 via Hootsuite
Pantel: Now onto prostate ca - multiplexed mRNA profiling of single CTCs from a single pt. AR-V7 expression and resp to Rx #MDxE16
4:26am April 5th 2016 via Hootsuite
Pantel: Heterogeniety of ER receptor in CTCs from breast ca pts '13 PLoS One https://t.co/13XwpZUgBh #MDxE16
4:25am April 5th 2016 via Hootsuite
Pantel: Onto HER2 oncogene in br ca: DETECT-III anti-HER2 Rx in metastatic br ca #MDxE16
4:24am April 5th 2016 via Hootsuite
Pantel: '14 Lancet Onc ref https://t.co/LFmfyfTlSa CTCs vs conventional tumor markers, 1900 pts meta-analysis #MDxE16
4:23am April 5th 2016 via Hootsuite
Pantel: Potential relevance: glioma pts w/CTCs not candidates for transplantation. #MDxE16
4:21am April 5th 2016 via Hootsuite
Pantel: '14 STM ref https://t.co/XVVl6qC141 for glioma multforma - detection of CTCs in 20% of pts. #MDxE16
Pantel: High-risk prostate ca - CTC-SCAN project, almost finished recruitment across 6 EU countries. #MDxE16
4:19am April 5th 2016 via Hootsuite
Pantel: Detection of CTC counts assoc'd w/unfavorable prognosis in early stage cancers. Lists pubs across cancer types #MDxE16
4:18am April 5th 2016 via Hootsuite
Pantel: Intermediate phenotypes may be most aggressive; high level of plasticity; distant tissue environmental factors #MDxE16
4:17am April 5th 2016 via Hootsuite
Pantel: Ephithelial to Mesenchymal transition - 'after 10's of thousands of papers later' intermediate E/M phenotypes have potential #MDxE16
4:16am April 5th 2016 via Hootsuite
Pantel: '16 Parsortix ref: https://t.co/WTgEgldzhL Also Cell Collector https://t.co/WXUigIXwvj tested. Can take CTCs and Xenoxplant #MDxE16
4:15am April 5th 2016 via Hootsuite
Pantel: CTCs/ctDNA 'may provide a more complete picture'. Many types of enrichment; size-based, EpCAM-based. Parsortix device #MDxE16
4:13am April 5th 2016 via Hootsuite
Pantel: Figure from '10 Nature Rev Clin Onc https://t.co/DButCpSnAL Metastasis biopsy may not capture heterogeneity #MDxE16
4:12am April 5th 2016 via Hootsuite
Pantel: And basic biology of cancer as well: many malignant cells can lie dormant for 10 years. Osteoclasts can influence outgrowth #MDxE16
4:09am April 5th 2016 via Hootsuite
Pantel: Most recent review: https://t.co/sxWWLrN1as Aims - screening, early det, est risk of relapse/met progression; stratification #MDxE16
4:08am April 5th 2016 via Hootsuite
Pantel: Refers to this '10 review https://t.co/oPcaxJzjqi Liquid biopsy has promising future, whether ctDNA, CTCs, exosomes #MDxE16
4:07am April 5th 2016 via Hootsuite
Klaus Pantel (Univ Hamburg-Eppendorf) Clinical implications of CTCs analysis #MDxE16
4:04am April 5th 2016 via Hootsuite
Live tweets from the Molecular Diagnostics Europe conference #MDxE16 https://t.co/psvbb2vaUS Circulating Tumor Cell (CTC) track
4:03am April 5th 2016 via Twitter Web Client
Featuring ctDNA RT @drbachinsky: Clinical Genomics May Turn Cancer Treatment Into Precision M... : Oncology Times https://t.co/DjkwneQ6p2
7:30pm April 2nd 2016 via Hootsuite
Math for kids! RT @pickover: Fill in the blanks so that each equation is correct. https://t.co/NW8X4Siwch https://t.co/X0egB4WNj7
6:25pm April 2nd 2016 via Hootsuite
RT @theNCI: What is the promise of #precisionmedicine in the treatment of cancer? We explain: https://t.co/4n5yqXd95c https://t.co/g3R7dJw6…
5:20pm April 2nd 2016 via Hootsuite
RT @KevinADavies: Whole-genome seq will replace genetic tests because it *is* all tests https://t.co/Qll400RAQC via @FT @clivecookson https…
5:16pm April 2nd 2016 via Hootsuite
Medical Testing Is So Hot Right Now. This Startup (CoFactor Genomics) Wants In | WIRED https://t.co/BYiQhFtqmt
1:25pm April 2nd 2016 via Hootsuite
Ancient mitochondrial DNA provides high-resolution time scale of the peopling of the Americas | Science Advances https://t.co/Iw8pTYM1YY
1:09pm April 2nd 2016 via Hootsuite
The FDA NGS-based Oncology Panels Workshop | Genomic Precision Blog @SeraCare https://t.co/6htNVQMbVj
9:00am April 2nd 2016 via Hootsuite
Guardant Health To Present Liquid Biopsy Data From More Than 10K Patients at #AACR16 Annual Meeting | BioSpace https://t.co/rJAHA8NReo
7:59am April 2nd 2016 via Hootsuite
Map: Zika could extend far deeper into US than experts said | Stat News https://t.co/jKcAaW7ZVJ
7:25pm April 1st 2016 via Hootsuite
Under pressure to digitize everything, hospitals are hackers’ biggest new target - The Washington Post https://t.co/yDYdLJYXOF
6:35pm April 1st 2016 via Hootsuite
How The Citizen Data Scientist Will Democratize Big Data - Forbes https://t.co/i7zxC4C6gj
5:25pm April 1st 2016 via Hootsuite
Everything you learned about the shape of DNA is wrong | Stat News https://t.co/C0UDjMpfP9
4:25pm April 1st 2016 via Hootsuite
PacBio Long-read sequence assembly of the gorilla genome | Science https://t.co/2CROdNRRm7
3:25pm April 1st 2016 via Hootsuite
Gorilla Genome Updated With PacBio Long Read Assembly | GenomeWeb https://t.co/e2M7jYqlAh
2:30pm April 1st 2016 via Hootsuite
RT @rahman_nazneen: Zika structure discovered, raising hopes for new ways to combat virus https://t.co/gWPGwHzPrg
1:25pm April 1st 2016 via Hootsuite
RT @hmtme: "The Roots of Bioinformatics in Theoretical Biology" PLoS Comput Biol. 2011 https://t.co/f7AL1oOBXL
12:55pm April 1st 2016 via Hootsuite
RT @NatureNews: Biology software promises easier way to program living cells https://t.co/Tcu1SAPfaU https://t.co/i4IkqiZ8ev
11:05am April 1st 2016 via Hootsuite
