Mardis: First at #AACR12 with a landscape; now to say 'we are on the brink... to change how pts are cared for' #AACR16
10:53am April 17th 2016 via Hootsuite
Elaine Mardis (Washington Univ Sch of Medicine St. Louis MO) Cancer genomics: A translational future #AACR16
10:51am April 17th 2016 via Hootsuite
RT @3NT: George Coukos giving fascinating talk on ovarian cancer immunotherapy in "meet the expert" session #AACR16 https://t.co/7QTOZonRdn
10:50am April 17th 2016 via Hootsuite
Jose Baselga (Memoral Sloan Kettering NY): Announcing US Vice President Joe Biden's appearance on Wed, and shows video abt his son #AAACR16
10:41am April 17th 2016 via Hootsuite
Previewing the American Association for Cancer Research 2016 Conference #AACR16 https://t.co/mQZLn969UA
10:37am April 17th 2016 via Hootsuite
Q: How are 'stem muts' determined? Dawson: Br ca follows both TP53 and CA 15-3; others are more difficult to determine #AACR16
8:56am April 17th 2016 via Hootsuite
RT @JFreemanDaily: Dawson: is circulating DNA ready for prime time? #AACR16 https://t.co/W7fVNNwlsX
8:54am April 17th 2016 via Hootsuite
New post: Previewing the American Association for Cancer Research Mtg #AACR16 @SeraCare Blog Genomic Precision https://t.co/6statJUkRd
8:53am April 17th 2016 via Hootsuite
Dawson: Feels that 'the time is right' for prospective clinical trials for ctDNA. #AACR16
8:50am April 17th 2016 via Hootsuite
Dawson: ctDNA kinetics parallel trtmt response to ABT-199 in CLL. Showed dynamic changes in trtmt responses #AACR16
8:49am April 17th 2016 via Hootsuite
Dawson: Unpubl datat: n=33, small panel of 7 genes, ID'd candidate muts for serial monitoring in 82% after ABT-199 trtmt #AACR16
8:40am April 17th 2016 via Hootsuite
Dawson: May be counter-intuitive to look at ctDNA when cells available: look at its presence in tissue compartment. #AACR16
8:39am April 17th 2016 via Hootsuite
Dawson: CLL review: std is chemo-immmunotherapy. New therapies shown, eg ABT-199. CLL found in lymph, periph blood, bone marrow #AACR16
8:38am April 17th 2016 via Hootsuite
Dawson: Hematological malignancies for ctDNA, not many studies '15 Lancet Oncol https://t.co/ryoLVuqpY1 #AACR16
8:36am April 17th 2016 via Hootsuite
Dawson: Tumor sampling from multiple sites, serial plasma: primary tumor at autopsy shows CN alteration; overlay of plasma data #AACR16
8:35am April 17th 2016 via Hootsuite
Dawson: Gastric pt w/no BRAF ampl; post-trtmt bowel tumor; BRAF ampl. TERT promoter didn't rise as much. Copy number vs abs quant Q #AACR16
8:33am April 17th 2016 via Hootsuite
Dawson: Treatment resistance. Initial response, original 8% BRAF V600E, day 367 reappeared w/NRAS Q61R #AACR16
8:31am April 17th 2016 via Hootsuite
Dawson: Showed TERT prom muts and ctDNA tracking closely clinical progression, two examples shown. #AACR16
8:30am April 17th 2016 via Hootsuite
Dawson: TERT promoter muts and ctDNA: cp to BRAF/NRAS, R^2=0.76 correlation. ctDNA and PET R^2=0.5 #AACR16
8:29am April 17th 2016 via Hootsuite
Dawson: Seeing NRAS-mut disease too, also seen. One pt with RAC1 P29S, close correlation to disease burden #AACR16
8:27am April 17th 2016 via Hootsuite
Dawson: ctDNA and disease burden: contrast visceral dis or nodal or bone mets (high); subcutaneous (lower) brain mets (even lower) #AACR16
Dawson: Showed several pubs (too fast) '15 ref https://t.co/SVdqjCwivZ of melanoma of ctDNA can correlate to tumor burden #AACR16
8:25am April 17th 2016 via Hootsuite
Dawson: TCGA Cell 2015 showed BRAF, NRAS, NF1, triple WT https://t.co/BisNHjmmSD Some work, not a lot. BRAF #AACR16
8:23am April 17th 2016 via Hootsuite
Dawson: Less explored - melanoma, hematological. Australia has highest rate worldwide. Showed '13 data, death rate going up#AACR16
8:21am April 17th 2016 via Hootsuite
Dawson: MRD tracking in early-stage br ca - one of three recent papers '15 STM https://t.co/G9XQPwsWWV #AACR16
8:20am April 17th 2016 via Hootsuite
Dawson: Follwoed mutations showing evidence of vol - GAS6, MED1, PDGFRA. Need fn valdiation; but a good screening / rsrch tool #AACR16
8:18am April 17th 2016 via Hootsuite
Dawson: '13 Nature https://t.co/3vvCJlUgnS Looked at WES of plasma, looking at acquired resistance in met br ca. #AACR16
8:17am April 17th 2016 via Hootsuite
Dawson: Pt agreed to multiple biopsies post-mortem; showed multiple mets (brain, chest, liver, vertebra etc.) and plasma ctDNA #AACR16
8:15am April 17th 2016 via Hootsuite
Dawson: This patient: stem mutations 'are best'; Rx was Tamoxifen, Trastuzumab, then Lapatinib,Capecitabine. #AACR16
8:14am April 17th 2016 via Hootsuite
Dawson: Recent '15 Nature Comm https://t.co/HsGbZDVFIi 3 key patterns: 'Stem muts'; 'metastatic clade'; 'private mutatations' #AACR16
8:13am April 17th 2016 via Hootsuite
Dawson: Across pts, across genes assayed for: similar dynamic changes. Also evidence of clonal heterogeneity shown (TP53 vs PIK3CA) #AACR16
8:11am April 17th 2016 via Hootsuite
Dawson: Showed Capecitabine and Carboplatin - ctDNA found rising 5 mo before radiology could show clin progression #AACR16
8:10am April 17th 2016 via Hootsuite
Dawson:Showed fig. that ctDNA reflected tumor burden, more sens than CA 15-3. CTCs were enriched by CellSearch #AACR16
Dawson: At Dx, at relapse, disease progression. '13 NEJM https://t.co/WiXxAM2RPE followed trad br ca biomarker CA15-3, ctDNA, CTC #AACR16
8:09am April 17th 2016 via Hootsuite
Dawson: Adv: minimally invasive; serial sampling; intratumor heterogeneity; molecular monitoring #AACR16
8:07am April 17th 2016 via Hootsuite
Dawson: Reviews methods: dPCR for single loci; targeted; WES/WGS. Tradeoff between sens. and coverage. #AACR16
8:04am April 17th 2016 via Hootsuite
Dawson: Her clinical focus is br ca. Starts with a photo of a Melbourne phsycian 1869 Thomas Ashworth; '48 Mandel and Metais #AACR16
8:02am April 17th 2016 via Hootsuite
Sarah-Jane Dawson (Peter MacCallum Cancer Ctr Victoria Australia) Liquid Biopsies: Monitoring the Cancer Genome in Blood #AACR16
8:00am April 17th 2016 via Hootsuite
Good morning #AACR16 and twitter followers - next 4 days of live-tweeting (when I can) from New Orleans https://t.co/E3RKT4Xwd9
7:58am April 17th 2016 via Hootsuite
'Life sciences... are infinitely more complex than computer systems.' | Washington Post https://t.co/0JXuuItPMo
9:32pm April 16th 2016 via Hootsuite
No pressure: NSF test finds eliminating deadlines halves number of grant proposals | Science | AAAS https://t.co/E5SalLdWtv
9:20pm April 16th 2016 via Hootsuite
Theranos: How to Blow $9 Billion in 6 Months | Fox Business https://t.co/9fODspR5dD
7:58pm April 16th 2016 via Hootsuite
Traveling to Mars at the 2016 Lockheed Martin USA Science & Engineering Festival today. https://t.co/6I19II2ZRx
10:49am April 16th 2016 via Hootsuite
Researchers have found an ‘alarming’ new side effect from eating fast food - The Washington Post https://t.co/bhGdj7mkYT
9:20pm April 15th 2016 via Hootsuite
Current Topics in Genome Analysis 2016 | https://t.co/j9lfUnDr0r https://t.co/PJekxuHN5E
8:20pm April 15th 2016 via Hootsuite
Cancers cells have mitochondrial DNA missing — Medium https://t.co/uCRqaypd9q
7:15pm April 15th 2016 via Hootsuite
A Prescription for Better Care — Medium https://t.co/iKZxol38Ni
6:15pm April 15th 2016 via Hootsuite
Bernie Sanders surrogate Dr. Song sells “false hope” to cancer patients for $150 a test | Dr. Jen Gunter https://t.co/8WNTqSuoew (Cynvenio)
5:40pm April 15th 2016 via Hootsuite
PHD Comics: Marriage v. The Ph.D. https://t.co/eBo1vU6f4Z
4:25pm April 15th 2016 via Hootsuite
RT @SeraCare: Jazzed for #AACR16! Visit us at booth 2552 and check out our 3 posters. More info here: https://t.co/L5xpYJlCMP https://t.co/…
3:49pm April 15th 2016 via Twitter Web Client
