RT @wef: #Millennials: ‘We expect to keep working till the day we die’ https://t.co/juosQUXs4v https://t.co/6hgZ80yc7b
1:05pm May 25th 2016 via Hootsuite
RT @robertmenzies: Impoverished background affects cancer risk later in life | CRUK https://t.co/2QnL6iKTBY
12:01pm May 25th 2016 via Hootsuite
No country for academics: Chinese crackdown forces intellectuals abroad | The Guardian https://t.co/5kd08fwEeM
11:10am May 25th 2016 via Hootsuite
Canadian Science Writers' Association - People's Choice Award for Fave Science Website https://t.co/Tk5cwEyHoF
10:01am May 25th 2016 via Hootsuite
Broken pottery reveals the sheer devastation caused by the Black Death - The Washington Post https://t.co/xSGUUmx4sX
9:00am May 25th 2016 via Hootsuite
Overtime pay for post-docs | Nature News https://t.co/cmnBroxpYS
8:00am May 25th 2016 via Hootsuite
Medicare Contractor Outlines Criteria for Analytical Validity of Circulating Tumor DNA Tests | GenomeWeb https://t.co/1J8S8gjMuI
7:55am May 25th 2016 via Hootsuite
China’s Science Revolution | BBC News https://t.co/a13McRLIph
6:55am May 25th 2016 via Hootsuite
For One Vermont Man, Sequencing His Whole Genome Solved A Life Of Pain | Vermont Public Radio https://t.co/wt9moUYTke
5:55am May 25th 2016 via Hootsuite
Two newborn deaths in the same family set off a race to solve a medical mystery | StatNews https://t.co/OKd71ZmwvO
4:55am May 25th 2016 via Hootsuite
RT @Luke_Hickey: Live stream of Roche Sequencing workshop at #ESHG2016 live now here: https://t.co/I8yMPfXJ05
3:54am May 25th 2016 via Hootsuite
RT @healthhashtags: Top Influencers of #eshg2016: @daleyuzuki @pacbio @genomebiology @eshgsociety @annekeluc Real-time Analytics: https://t…
12:20am May 25th 2016 via Hootsuite
RT @guardianscience: 'Eye-watering' scale of Black Death's impact on England revealed https://t.co/lT6G4tVj0S
9:20pm May 24th 2016 via Hootsuite
Where people drink the most booze and do the most drugs - The Washington Post https://t.co/rU4VHKfUBe
8:55pm May 24th 2016 via Hootsuite
RT @FiveThirtyEight: How your gut affects your mood: https://t.co/QkSlqbIepF https://t.co/Xu5R7szNu8
7:20pm May 24th 2016 via Hootsuite
Language Shrapnel – the challenge of profanity in print - The Chronicle of Higher Education https://t.co/aT0PViTSeE
6:40pm May 24th 2016 via Hootsuite
Keeping Busy May Prevent Memory Loss With Aging | NPR https://t.co/3bBD9yW9EY
4:40pm May 24th 2016 via Hootsuite
RT @EricTopol: Some useful data on prescription meds in the US https://t.co/3h5G0P0hy2 by @haleybureau @TIMEHealth https://t.co/CHfoyxjZQ3
3:31pm May 24th 2016 via Hootsuite
Garieri: Major markers are over-represented in the library. So need to find signatures for individ cell types. #ESHG2016
6:11am May 24th 2016 via Hootsuite
Garieri: Proportion 'quite different' than by gene exp. Can detect difference in cell size; clustering w/o main marker not clr #ESHG2016
6:09am May 24th 2016 via Hootsuite
Garieri: Across genes - INS, GCG, SST, PPT - can ID types, and proportions. Orthogonal - used branched DNA smFISH (Adv Cell Dx?) #ESHG2016
6:07am May 24th 2016 via Hootsuite
Garieri: 251 whole islets, 60 FACS beta cells. Ended up w/220 cells. Exp of INS gene: bimodal #ESHG2016
6:05am May 24th 2016 via Hootsuite
Garieri: Diabetes causes 1.5M deaths ('12) Five cell types, goal is to ID novel markers for each. 3 non-diabetic indiv s.c. islets #ESHG2016
6:04am May 24th 2016 via Hootsuite
Marco Garieri (Univ Geneva Switzerland) Single-cell RNA-seq analysis of human pancreatic islets #ESHG2016
6:03am May 24th 2016 via Hootsuite
Ferreira: Conclude: No new protein-coding genes, but new splice variants discovered. #ESHG2016
5:58am May 24th 2016 via Hootsuite
Ferreira: Ex - DPAGT1, assoc'd with disorder in glycosylation. Many novel exons leading to re-annotation #ESHG2016
Ferreira: Also testing limit with Dx genes. Used @PacBio to get full-length transcripts. On testis, >1.5K novel splice junctions #ESHG201
5:57am May 24th 2016 via Hootsuite
Ferreira: Testing limit of annotation w/MassSpec data. 52M spectra (data from Wrigth et al Nature Comm in press) #ESHG2016
5:55am May 24th 2016 via Hootsuite
Ferreira: Were able to validate 13,091/16,787 (78%) using GTEx and ENCODE; latter work validated 53% 664/1,243 targeted junctions #ESHG2016
5:52am May 24th 2016 via Hootsuite
Ferreira: Lower conf transcripts - EST, novel. using RT-PCRseq from 7 organs. Gene-spec primers, look at 18,030 splic junctions #ESHG2016
5:50am May 24th 2016 via Hootsuite
A. Ferreira (Swiss Inst Bioinf) Assessment of the GENCODE annotation through experimental validation #ESHG2016
5:49am May 24th 2016 via Hootsuite
Lerga-Jaso: Second class impact gene exp; inversions as cis or trans eQTLs. #ESHG2016
5:41am May 24th 2016 via Hootsuite
Lerga-Jaso: One signature - natural selection, where protein fn affected. Fig from '15 ref https://t.co/QqactnS2NO #ESHG2016
5:40am May 24th 2016 via Hootsuite
Lerga-Jaso: Looking at landscape, to char signature of inversion. Also impact on gene expression INVFEST project #ESHG2016
5:36am May 24th 2016 via Hootsuite
J. Lerga-Jaso (Univ Barcelona Spain) The landscape of polymorphic inversions and their functional impact in the human genome #ESHG2016
5:34am May 24th 2016 via Hootsuite
Stamoulis: Expression difference in sc fold-change same as bulk; gene dosage. Looking at random ASE as hypothesis #ESHG2016
5:23am May 24th 2016 via Hootsuite
Stamoulis: Use T21, from DZ twins but are discordant for Downs. T13, T18, T8 too. Used C1 (Fluidigm) #ESHG2016
5:19am May 24th 2016 via Hootsuite
Stamoulis: Until now studies have been done in bulk. But are trisomic cells have gene-dosage effect at single-cell level? #ESHG2016
5:18am May 24th 2016 via Hootsuite
G. Stamoulis Single cell allele specific exp (ASE) in common trisomies: gene dosage effects in Down syndrome, common aneuploidies #ESHG2016
5:17am May 24th 2016 via Hootsuite
Q: Any RNA profiling of these cells? Forsberg: Exciting preliminary data, shifting entire global expression pattern w/LOY #ESHG2016
5:16am May 24th 2016 via Hootsuite
Q: Fn of Y-chr in contribution? Forsberg: May be immunosurveillance #ESHG2016
5:14am May 24th 2016 via Hootsuite
Forsberg: 15-20% of >60yo men (>10% cells); survival only 1/2 as long #ESHG2016
5:12am May 24th 2016 via Hootsuite
Forsberg: LOY (loss of chrY) in men, describes prevalence (on the order of 5-8% >60y). Ass'n w/ AD '16 https://t.co/mxJL7GTVLS #ESHG2016
5:11am May 24th 2016 via Hootsuite
L.A. Forsberg (U Uppsala) Mosaic loss of chromosome Y (LOY) in peripheral blood increased risk of cancer and AD #ESHG2016
5:08am May 24th 2016 via Hootsuite
.@Sandi_Dheensa While looking around I did find this for VUS reporting: https://t.co/xgdqtE5P1S
4:53am May 24th 2016 via Hootsuite in reply to Sandi_Dheensa
.@Sandi_Dheensa I haven't followed reporting of VUS to pts very closely I admit - relaying what M-C King said about it though, makes sense
4:49am May 24th 2016 via Hootsuite in reply to Sandi_Dheensa
MT @genomicsedu: Mary-Claire King at #ESHG2016 opening up BRCA1/2 screening. More information on her work: https://t.co/yayWQ3aOkU
4:46am May 24th 2016 via Hootsuite
Mandel: Factor V Leiden: widely performed, little or no real clinical application. No guidelines from expert societies #ESHG2016
3:58am May 24th 2016 via Hootsuite
Mandel: Obvs application: genotype-guided dosage of Warfarin. But 3 papers in Dec '15 NEJM large studies, 'no effect' or 'modest' #ESHG2016
3:57am May 24th 2016 via Hootsuite
Mandel: With >5,000 genetic diseases, need pt and family involvement for natural history #ESHG2016
3:51am May 24th 2016 via Hootsuite
