Harnessing the Immune System to Fight Cancer - The New York Times https://t.co/fBxM455C2T
12:50pm July 31st 2016 via Hootsuite
Noninvasive Prenatal Screening Can Replace Current Trisomy Screening in All Age Groups, ACMG Says | GenomeWeb https://t.co/YqB2Y1HzOq
11:24am July 29th 2016 via Hootsuite
Extensive sequencing of seven human genomes to characterize benchmark reference materials : Scientific Data #GIAB https://t.co/R2tYH99rPP
4:29pm July 28th 2016 via Hootsuite
Helix CEO Predicts 90 Percent of Global Population Will Be Sequenced in 20 Years | GenomeWeb ($) https://t.co/9Kud6vk25h
6:20pm July 25th 2016 via Hootsuite
Humans once opposed coffee and refrigeration. Here’s why we often hate new stuff. - The Washington Post https://t.co/z1Qwv9O5oZ
6:10pm July 25th 2016 via Hootsuite
The downside of being happy - The Washington Post https://t.co/rWLKiEJ3dB
4:25pm July 25th 2016 via Hootsuite
RT @drbachinsky: Ray Kurzweil: The world isn’t getting worse — our information is getting better https://t.co/oOhPfdFkTu
3:05pm July 25th 2016 via Hootsuite
MT @personalizedmed: 3 #digitalhealth strategies 1) broad access, 2) clinical workflow, 3) data in the cloud https://t.co/BYhFMMr6aL
1:55pm July 25th 2016 via Hootsuite
Uncle Sam Wants You — Or at Least Your Genetic and Lifestyle Information - The New York Times https://t.co/JDh7zT2mjh
12:39pm July 25th 2016 via Hootsuite
Biomarker development in the precision medicine era: lung cancer as a case study : Nature Reviews Cancer https://t.co/3XfEgbwyhF
12:29pm July 25th 2016 via Hootsuite
101 Biggest Product Failures - Corporate Innovation Gone Wrong https://t.co/Y6V8C0WQj4
11:36am July 25th 2016 via Hootsuite
California Precision Medicine Initiative Unveils $7.2M Funding Opportunity | GenomeWeb https://t.co/YSYICmLvG6
9:55am July 25th 2016 via Hootsuite
Fix Your Social Media Strategy by Taking It Back to Basics https://t.co/ZXTpE4R5nQ
8:57am July 25th 2016 via Hootsuite
The VCR is officially dead. Yes, it was still alive. - The Washington Post https://t.co/Rl3DSuPrMT
2:40pm July 24th 2016 via Hootsuite
Two Middle East locations hit 129 degrees, hottest ever in Eastern Hemisphere, maybe the world - The Washington Post https://t.co/8rT7hSndqW
1:40pm July 24th 2016 via Hootsuite
Gold iPhone 5S 16GB in gently-used, almost-new condition (yes I'm 'lightening the load') via Swappa https://t.co/1bYRvzhn5f
12:14pm July 24th 2016 via Twitter Web Client
A New Exploit Could Let Hackers Take Over your iPhone | Digital Trends https://t.co/vHPo7gAvh8
3:39pm July 22nd 2016 via Hootsuite
RT @SeraCare: Someone got #Zika in Utah and no one knows how https://t.co/TejAwzmq08 https://t.co/lnYO3nD9D7
11:28am July 22nd 2016 via Hootsuite
The New York Public Library’s little-known “human Google” service answers any question by phone — Quartz https://t.co/tgXhttDB5l
6:45pm July 20th 2016 via Hootsuite
Be authentic out there, people! https://t.co/mqTG2fuZjI
1:41pm July 20th 2016 via Hootsuite
There’s good news to be found in the global economy, if you know where to look — Quartz https://t.co/Fjleh59fq6
9:40am July 20th 2016 via Hootsuite
Clinical Genomics Approach Offers Increased Diagnostic Yield for Intellectual Disability | GenomeWeb https://t.co/7M6W6DfbKn
7:25am July 20th 2016 via Hootsuite
RT @drbachinsky: Developments in high throughput sequencing – July 2016 edition https://t.co/G9Jt1mEVii via @lexnederbragt
6:10am July 20th 2016 via Hootsuite
Florida may have first local Zika case in U.S.| Seeking Alpha https://t.co/gmh4ArAeQF
5:33am July 20th 2016 via Hootsuite
10,000 genomes deeply examined in study led by Craig Venter. | https://t.co/sez1i2XGW5 https://t.co/351qrmVaxC
6:00pm July 19th 2016 via Hootsuite
Counting the Extra Footsteps From Pokémon Go Mania - Bloomberg https://t.co/DExDQYNbXg
4:30pm July 19th 2016 via Hootsuite
Talasaz: Mentions need for standard reference materials for ctDNA (e.g. @SeraCare) https://t.co/oLi6HXBQFX #FDA_AACR
2:59pm July 19th 2016 via Hootsuite
Eerkes: Orthogonal comparators (showed figure from '15 Clin Cancer Res) https://t.co/4LeDyxE4iM #FDA_AACR
2:55pm July 19th 2016 via Hootsuite
Eerkes: GE is depth of clone coverage, measured by number of unique fragments. #FDA_AACR
2:54pm July 19th 2016 via Hootsuite
Eerkes: Look at GE (genome equiv) in the context of complexity in the sample. 500GE vs 5,000GE: LOD 1% vs 0.05% w/reproducibility #FDA_AACR
Stephens: You need to understand the plasma ctDNA signal in the context of thousands of tissue samples. #FDA_AACR
2:42pm July 19th 2016 via Hootsuite
Tera Eerkes (ResolutionBio) Tissue to plasma concordance; plasma to plasma concordance also useful. #FDA_AACR
2:41pm July 19th 2016 via Hootsuite
Talasaz: Did have one ctDNA pos, tissue-neg, of an ALK fusion; pt responded to crizotinib. '14 launched NEXT-2 prospective study #FDA_AACR
2:38pm July 19th 2016 via Hootsuite
Panelists from ResolutionBio, Roche, Grail, PGDx, AmirAli Talasaz of Guardant. Talasaz - PPV from 94%-100% #FDA_AACR
2:34pm July 19th 2016 via Hootsuite
Q: Contrived vs pt specimens? Stephens: 1/4 cell line, 1/4 pts. Can do more thorough validation with contrived samples #FDA_AACR
2:28pm July 19th 2016 via Hootsuite
Q: Use of barcodes? Stephens: Use double-stranded error correction. Manuscript in Q3-Q4 of '16 #FDA_AACR
2:27pm July 19th 2016 via Hootsuite
Stephens: 1/4 - 1/3 of pts are being missed for standard-of-care Rx; more for liquid biopsies, unless validation takes place #FDA_AACR
2:25pm July 19th 2016 via Hootsuite
Stephens: (and if background is only 5 copies...) 'There is no room for error or omission in the care of pts with cancer' #FDA_AACR
2:24pm July 19th 2016 via Hootsuite
Stephens:AF's at 0.5% and 1% for SNVs, indels, fusions. But focal amplifications were down to 5%. CMET typically 7 copies #FDA_AACR
Stephens: Depth and uniformity both impt; shows data of 100% sens, 98.8% PPV for small indels #FDA_AACR
2:21pm July 19th 2016 via Hootsuite
Stephens: Also used synthetic spike-ins to low MAF. Intra- and inter-run concordance. Showed effect of improper storage on ctDNA #FDA_AACR
2:19pm July 19th 2016 via Hootsuite
Stephens: Est accuracy of test before launch - sens and spec (PPV) for subst., indels, gene fusions, CNA. Mixtures of cell lines #FDA_AACR
2:18pm July 19th 2016 via Hootsuite
Stephens: ctDNA assay ID'd a FP EGFR mutation. Dozens of examples - underscoring challenge of analytic validation #FDA_AACR
2:17pm July 19th 2016 via Hootsuite
Stephens:Potential treatment ramifications of poorly validated assay dev: CCDC6-RET fusion pt, 36 y/o female StgIV #FDA_AACR
2:16pm July 19th 2016 via Hootsuite
Stephens: ctDNA is present at <1% purity; 'orders of magnatude more difficult' than tissue #FDA_AACR
2:12pm July 19th 2016 via Hootsuite
Stephens: 65% of pts harbor a clin relevant alteration via FoundationOne. 26% EGFR mutations are missed; 30% ALK fusions missed #FDA_AACR
2:11pm July 19th 2016 via Hootsuite
Stephens: More effective and less toxic. From discovery on RET fusions (2/12) to first treatment (3/13). #FDA_AACR
2:10pm July 19th 2016 via Hootsuite
Phil Stephens (Foundation Medicine) Analytical and clinical validation of liquid biopsy tests #FDA_AACR
2:07pm July 19th 2016 via Hootsuite
Tzou: Contrived specimens - how was it done? Effect of shearing? Dependency of detection method? Background and how much? #FDA_AACR
1:57pm July 19th 2016 via Hootsuite
Tzou: Discordance can mean different things - inconsistency, non-comparable ranges, non-uniform across scope of analytes #FDA_AACR
1:54pm July 19th 2016 via Hootsuite
