Jackson Laboratory to Launch Actionable Cancer Gene Panel as Clinical Dx Lab Grows | GenomeWeb ($) https://t.co/9NzLIvvubu
3:05pm August 31st 2016 via Hootsuite
Fired Researcher Charged With Attempted Murder | GenomeWeb https://t.co/QFUe29XOVv
1:50pm August 31st 2016 via Hootsuite
Pokémon Go and the lifespan of fads in the Internet age - The Washington Post https://t.co/4RsFJDCOIZ
1:41pm August 31st 2016 via Hootsuite
Theranos Halts New Zika Test After FDA Inspection - WSJ https://t.co/JfDSXZx5Iw
12:51pm August 31st 2016 via Hootsuite
23andMe has a problem when it comes to ancestry reports for non-Whites — Quartz https://t.co/gkCPvzVKzK
8:45am August 30th 2016 via Hootsuite
Daily chart: Revenge of the nerds (STEM graduates) | The Economist https://t.co/6gwKnbR23Z
7:30pm August 29th 2016 via Hootsuite
The real reason this elephant chart is terrifying – NewCo Shift https://t.co/DP3sCObNQE
6:12pm August 29th 2016 via Hootsuite
Not a Drill: SETI Is Investigating a Possible Extraterrestrial Signal From Deep Space | Observer https://t.co/g8Qq8H0nvF
4:33pm August 29th 2016 via Hootsuite
"Rules of human behavior have changed little in the last 4,000 years" — Quartz https://t.co/pjAnyGbjoq
3:32pm August 29th 2016 via Hootsuite
DNAe Develops Semiconductor DNA Technology for Rapid Sepsis Diagnostic Testing | GenomeWeb https://t.co/3A9GfdQK3c
3:22pm August 29th 2016 via Hootsuite
Potential Zika Virus Therapies Identified by Researchers - WSJ https://t.co/ZLXQxpxI0d
2:01pm August 29th 2016 via Hootsuite
Clinical Trials Doctors Demand Ownership Of Patients' Data | Forbes https://t.co/VcB2gyltjH
11:08am August 29th 2016 via Hootsuite
Mad About Epipen? Here Are Some Ideas To Actually Fix America's Drug Pricing Mess https://t.co/SS42RQZcT6
7:56am August 29th 2016 via Hootsuite
FDA takes radical measure of recommending Zika screening for entire U.S. blood supply - The Washington Post https://t.co/y1LAGwwcUr
5:21pm August 26th 2016 via Hootsuite
.@h2so4hurts I certainly am cognizant of that most valuable commodity, your TIME. They aren’t making any more of it, you know!
4:10pm August 26th 2016 via Hootsuite in reply to h2so4hurts
.@granitehead Just had not heard of that before...
11:56am August 26th 2016 via Hootsuite in reply to granitehead
Allayee: Going to a nutrigenetic clinical trial - hispanic 12-18yo, randomized group for 16w w/dietary intervention, sugar reduction #NGDx16
11:31am August 26th 2016 via Hootsuite
RT @h2so4hurts: Yang Cao giving a clinic on why NIPT testing is a screening test and will never be a diagnostic one #NGDx16 #KillingIt.
11:30am August 26th 2016 via Hootsuite
@h2so4hurts Great to see you in-person here at #NGDx16 - hopefully will be able to pay a visit in-person later this Fall. (Headed out...)
11:29am August 26th 2016 via Hootsuite
Allayee: Diet and fat in liver levels - PNPLA3 variant and sugar intake w/high fasting triglycerides. #NGDx16
11:26am August 26th 2016 via Hootsuite
Allayee: Dev a genetic risk score and mean liver fat %; prognostic value of BMI, showed ROC (from '13 ref) genes not large predictor #NGDx16
11:22am August 26th 2016 via Hootsuite
Allayee: Genotyping six loci in Hispanic children - '13 ref https://t.co/jKvcJuPD1D elevated liver fat (20x) at 10yo #NGDx16
11:20am August 26th 2016 via Hootsuite
Allayee: Dallas heart study in '08 PNPLA3 https://t.co/etEMIwqdWD Much higher in hispanics; followup found 5 add'l risk loci #NGDx16
11:19am August 26th 2016 via Hootsuite
Allayee: Risk for heptaocellular carcinoma. For liver fat, difficult to Dx using only biomarkers. 92% of NAFLD have BMI >95 %'ile #NGDx16
11:17am August 26th 2016 via Hootsuite
Allayee: Fatty liver disease (45% in hispanics), 20-25% in adults. A public health problem associated with obesity. #NGDx16
11:14am August 26th 2016 via Hootsuite
Allayee: Not only heard disease, but also can be generalized for other common disease (eg diabetes) #NGDx16
11:13am August 26th 2016 via Hootsuite
Allayee: Even with all this, a tiny fraction of the missing heritability. Not a lot of gene-gene, gene-env for CAD, nor epigenet #NGDx16
Allayee: Another ex of WGS and rare vars LoF lipid metabolism https://t.co/2tKzLvFTQS PCSK9 with lower LDL. #NGDx16
11:12am August 26th 2016 via Hootsuite
Allayee: But affect on cardiologists? Opportunity for biol targets... Rare vars: shows review of 9 papers. https://t.co/yuXhunUaFX #NGDx16
11:10am August 26th 2016 via Hootsuite
Allayee: For coronary artery disease: via large 185K GWAS, 50 loci, prevalance in high % of population. #NGDx16
11:08am August 26th 2016 via Hootsuite
Allayee: Reviews genetics of complex disease - common vars, rare vars, gene-gene, gene-env, microbiome #NGDx16
11:07am August 26th 2016 via Hootsuite
Hooman Allayee (USC) Emerging aspects of genetic studies in humans and implications for informing dietary recommendations #NGDx16
11:06am August 26th 2016 via Hootsuite
Chung: Women over 30, BRCA in AJ women, no cancer history; universal screening extends life expectancy by 3.5y vs history-based #NGDx16
10:03am August 26th 2016 via Hootsuite
Chung: Biggest area cancer germline genetic tests; BRCA, breast, lynch, colorectal, neuroendocrine, gynecological, gastrointestinal #NGDx16
10:01am August 26th 2016 via Hootsuite
Chung: Building genotypes into EMRs 'have held us back'. Onto Tier 2 warfarin testing, hasn't proven to be revolutionary #NGDx16
9:59am August 26th 2016 via Hootsuite
Chung: PGx tiers of uti Tier 1 are FDA labeled, reimbursed, used daily. CF. NSCLC, unresectable met melanoma, AML, CML, HIV #NGDx16
Chung: PGx has had a 'rocky path but an obvious area'. ACMG-56 for medically actionable conditions; heritable cancers #NGDx16
9:57am August 26th 2016 via Hootsuite
Chung: But PPV is about 60% for younger women, higher for older; 'still not 100%'. Shows PPV calculator https://t.co/ZHg6qvWChg #NGDx16
Chung: Charts PPV by maternal age, between older combined screening vs NIPS. Shows chart of Sens/Spec at >99% across tests #NGDx16
9:56am August 26th 2016 via Hootsuite
Chung: Aggregate - highlights microdeletions, less reliable PPV much much less than aneuploidies #NGDx16
9:54am August 26th 2016 via Hootsuite
Chung: Non-invasive prenatal screening: shows example z-score data; 'now a commodity'. 5 company's, 9-10 weeks, conditions listed #NGDx16
Chung: Carrier screening - SQNM, Counsyl, LabCorp, Pathway, NxGen MDx. testing 311 to 23 conditions. #NGDx16
9:52am August 26th 2016 via Hootsuite
Chung: But for CF, people make decisions to continue pregnancies, now some Rx. #NGDx16
9:51am August 26th 2016 via Hootsuite
Chung: What do people do w/carrier screening? Tay-Sachs. Now for her, it has been 5y since she has seen a case. #NGDx16
Chung: Asian, 1:94, thus $3.6M for 1 CF affected case if Asian. What we do today. #NGDx16
9:50am August 26th 2016 via Hootsuite
Chung: Another 96 men, x $100, and 4 prenatal test x $2K. $248K for 1 fetus, due to 1/24 prevalence #NGDx16
9:49am August 26th 2016 via Hootsuite
Chung: Whose resp to follow VUS over time? Issue - cost to ID 1 affected CF case in Ashkenazi. $248K = 2,304 women, $100/test. #NGDx16
Chung: Doing sequencing, variation still too many VUS where mis-Dx, effect on pts (psychosocial, emotional) #NGDx16
9:48am August 26th 2016 via Hootsuite
Chung: Started with targeted known muts for genotyping; and known for spec populations. But Fragile X, SMA - problems #NGDx16
9:46am August 26th 2016 via Hootsuite
Chung: These are tough w/ single test; thus for newborns, need tiered test for staging. Specific examples - carrier, NIPS, cancer #NGDx16
9:45am August 26th 2016 via Hootsuite
