Fabien Calvo (Gustave Roussey, France: From ICGC to ICGCmed #MAP16
5:19am September 23rd 2016 via Hootsuite
Siu: 'And patients welcome this idea'. Yesterday's NEJM https://t.co/CVtQsSmluW One example is ROS1-ers https://t.co/AX8EYPFpy9 #MAP16
Siu: Plan to use REDCap project from MSKCC; the deliverable is the data sharing. Showed a changed consent form for this. #MAP16
5:15am September 23rd 2016 via Hootsuite
Siu: BC Cancer Agency, and Princess Margaret / UHN, starting a Terry Fox CCC effort to share between Vancouver/Toronto #MAP16
5:14am September 23rd 2016 via Hootsuite
Siu: The goal is eventually to open up access. Cancer-LINQ ref: https://t.co/rUHux3H8Dm #MAP16
5:12am September 23rd 2016 via Hootsuite
Siu: Other projects - Project Genie; Orien; Oncology Precision Network; ASCO Cancer-LINQ has millions of EHRs moving to clin seq #MAP16
5:10am September 23rd 2016 via Hootsuite
Siu: Other initiatives - BRCA challenge, Cancer Gene Trust; sharing spec variants. both are open access #MAP16
5:09am September 23rd 2016 via Hootsuite
Siu: From NEJM 22 Sept from Staudt at the NCI: Toward a shared vision for cancer genomic data https://t.co/2Td3DhKKhI #MAP16
Siu: Conclude - no uniform approach for collecting data for precision medicine, even ethical procedures. #MAP16
5:06am September 23rd 2016 via Hootsuite
Siu: No 1 barrier to datasharing: "lack of funding"; the q is not only infrastructure, but who will standardize the data to share it #MAP16
5:05am September 23rd 2016 via Hootsuite
Siu: Shared demographic, and data capture results from ASCO slides; Most were research or dx/research; efficacy is nuanced result #MAP16
5:04am September 23rd 2016 via Hootsuite
Siu: n=59, ASCO abstract: https://t.co/ounzzDwjhu Heavy N.Am, EU; 'China was very difficult' #MAP16
5:00am September 23rd 2016 via Hootsuite
Siu: ... seq platforms, ethical concerns, funding sources, perceived barriers to datasharing. 97 questions #MAP16
4:59am September 23rd 2016 via Hootsuite
Siu: Performed a survey reported at ASCO - determining barriers to effective datasharing; looked at demographics, data collection... #MAP16
4:58am September 23rd 2016 via Hootsuite
Siu: Another - @GA4GH has many countries involved to create best-practices '16 Nature Med ref https://t.co/rPMKcvGl8t #MAP16
4:57am September 23rd 2016 via Hootsuite
Siu: So much data is buried; Cancer Moonshot Blue Ribbon draft quote - a National Cancer Data Ecosystem PDF: https://t.co/9AlWGpoaPd #MAP16
4:55am September 23rd 2016 via Hootsuite
Lilian Siu (Princess Margaret CC, Toronto, Canada) Datasharing initiatives in Precision Medicine #MAP16
4:51am September 23rd 2016 via Hootsuite
Soria: Showed several examples of improvement by disease type. Cholangiocarcinoma - PFS >6mo = 37%, clear Hazard R improvement #MAP16
4:49am September 23rd 2016 via Hootsuite
Soria: PFS comparison - null Hypothesis, PFS >1.3 = 15%. #Got PFS Ratio >1.3 = 33% Distribution: 20% of pts have PFS 2x MAP16
4:44am September 23rd 2016 via Hootsuite
Soria: MTB n=949; portrait n=844; n=411 had actionable. But matched Rx n=199, so only 20% rec'd matched Rx #MAP16
4:43am September 23rd 2016 via Hootsuite
Soria: By class: PI3K/AKT/mTOR, then ERBB2, FGFR. MOSCATO excluded pts with specific molecular defaults for which MTA avail. #MAP16
4:42am September 23rd 2016 via Hootsuite
Soria: But RNAseq ~10%. Showed distribution of frequent alterations by type; similar to TCGA results. BrCa PIK3CA after TP53 etc #MAP16
4:41am September 23rd 2016 via Hootsuite
Soria: Showed distribution of types - GI, urological, then lung. aCGH and NGS targeted 'equally efficient to drive Rx' about 30% ea #MAP16
4:40am September 23rd 2016 via Hootsuite
Soria: #MAP16 Recent Press Release announcing results: https://t.co/UBK6LxRmW4 950pts, NGS, RNAseq, WES too (in smaller #'s).
4:39am September 23rd 2016 via Hootsuite
Soria: Single site, fresh tumor, 18ga needle, <21d from biopsy to clin decision. cellularity >30%. aCGH, PGM seq #MAP16
4:37am September 23rd 2016 via Hootsuite
Jean-Charles Soria (Villejuif, France) @jsoriamd : MOSCATO-01 trial - asking whether molecular profiling will improve outcomes #MAP16
4:33am September 23rd 2016 via Hootsuite
Unicancer (France); ESMO: 57% EU, 20% Asia-Pac. OncologyPRO portal for education; clin practice; several meetings. Two OA journals #MAP16
4:31am September 23rd 2016 via Hootsuite
Swanton: 'The precision-oncology illusion'. https://t.co/1xBciDyPdF PFS in SHIVA trial (le Tourneau et al) #MAP16
4:29am September 23rd 2016 via Hootsuite
Swanton: Perspective in Nature J - only 1.6% can benefit; 'but the denominator is never mentioned' of the super-responders. #MAP16
4:26am September 23rd 2016 via Hootsuite
Swanton: CRUK's major goal: '70's 25% survival cancer rate; today ~50%; goal in 20y to make it 75% #MAP16
4:23am September 23rd 2016 via Hootsuite
Swanton: Oct 13-17 2017 is the next conference, Zurich Switzerland. CRUK: 'largest cancer fundraising institute', 400M GBP. #MAP16
4:22am September 23rd 2016 via Hootsuite
Charles Swanton: Introduces the 2nd meeting: 'Bridging the gap between research, academia and the clinic. Health economics, targets #MAP16
4:21am September 23rd 2016 via Hootsuite
Sept 23-24 will be live-tweeting the Molecular Analysis for Personalized Therapy Conference Agenda here: https://t.co/hDAtySNvKn #MAP16
4:19am September 23rd 2016 via Hootsuite
Student Debt Is Tied to Lower Grades Among College Students - Real Time Economics - WSJ https://t.co/PoTg23I8bB
9:05pm September 22nd 2016 via Hootsuite
Living with a partner can half risk of becoming overweight, study finds | Telegraph UK https://t.co/M4Mbxl1iq3
8:05pm September 22nd 2016 via Hootsuite
Breakthrough Gene Technology Attracts Investors Amid Patent Dispute - WSJ https://t.co/sK8j3VlmqJ
7:00pm September 22nd 2016 via Hootsuite
The secret to a happy marriage: it's all in your height difference - Telegraph https://t.co/DyaD9NZVNW
6:50pm September 22nd 2016 via Hootsuite
Laboratoire CERBA Adopts Seraseq™ Aneuploidy Reference Materials for Non-Invasive Prenatal Testing (NIPT) | Yahoo https://t.co/JyNDJO5wgB
6:25pm September 22nd 2016 via Hootsuite
Microsoft Announces Minecraft: Education Edition Launch 1 Nov | Techweek Europe https://t.co/E1TYXMYCTK
5:45pm September 22nd 2016 via Hootsuite
Why Do Famous People Get Paid $250,000 to Give a Speech? | Priceonomics https://t.co/MDYh8hc6Om
4:31pm September 22nd 2016 via Hootsuite
Bioengineering Prof Wins 'Genius Grant' For Inspiring Students To Invent Ingenious Medical Devices : NPR https://t.co/DkwDNnUbl5
4:20pm September 22nd 2016 via Hootsuite
]Public Workshop - Adapting Regulatory Oversight of NGS-Based Tests - Sept 23, 2016 | FDA https://t.co/x6Z2fAZwnG
3:05pm September 22nd 2016 via Hootsuite
Meet the Class of 2016 - MacArthur Foundation https://t.co/cegIwiEHMs
2:05pm September 22nd 2016 via Hootsuite
Microsoft will 'solve' cancer within 10 years by 'reprogramming' diseased cells | Telegraph UK https://t.co/ajouFWyRWT
12:54pm September 22nd 2016 via Hootsuite
Chan Zuckerberg Initiative Announces $3 Billion Investment To Cure All Disease : NPR https://t.co/QU5R3OSY3m
9:50am September 22nd 2016 via Hootsuite
NYC Chelsea bomber name: Prejudice against ethnic-sounding names forces people to question their identities — Quartz https://t.co/Zktl0jlmgz
6:09am September 22nd 2016 via Hootsuite
Genentech dives into mRNA, betting $310M on BioNTech’s personalized cancer vaccine tech – ENDPOINTS https://t.co/ptHhwTShdr
11:40am September 21st 2016 via Hootsuite
Even an extra five pounds can hurt your job chances - The Washington Post https://t.co/oCKkPXrKnD
11:27am September 21st 2016 via Hootsuite
Cut-throat academia leads to 'natural selection of bad science', claims study | Science | The Guardian https://t.co/agcmNqwvMR
10:28am September 21st 2016 via Hootsuite
The Economic Woe of Young Liberal-Arts Majors - The Atlantic https://t.co/MkQ779FHui
5:31pm September 20th 2016 via Hootsuite
