Pralahad: Go back with dyes, Ab-conj, to interogate cells on the 2D slide surface. First: mCRPC (metastatic chemo-resist Prostate C) #PMWC17
2:49pm January 24th 2017 via Hootsuite
Outgoing FDA Commissioner, Pharma, Investors Discuss Regulation at #PMWC17 | GenomeWeb ($) https://t.co/LO4FHXCQA2
2:48pm January 24th 2017 via Hootsuite
Pralahad: Makes the case for CTCs monitoring complex, metastatic disease. Look at all nucleated cells, find shape-based outliers #PMWC17
2:46pm January 24th 2017 via Hootsuite
Murali Pralahad (EPIC) Actionable, accurate and accessible liquid biopsy #PMWC17
2:43pm January 24th 2017 via Hootsuite
Pla: And spec shown per-sample, not per-base. They require 2x 10mL blood, spec. >99% on a per-sample basis #PMWC17
2:42pm January 24th 2017 via Hootsuite
Pla: Lack of standardization how data is reported, can mislead. No single measure - report sens for SNVs, indels, Fusions, CNV gain #PMWC17
2:41pm January 24th 2017 via Hootsuite
Pla: Analytical performance - base specificity, incorrect calls/sample based on 100kb panels has 100 incorrect calls at 99.9% #PMWC17
2:40pm January 24th 2017 via Hootsuite
Frederick Pla (Genomic Health): Timelines for adoption of ctDNA to $26B market depending on indication. Oncotype SEQ Liquid Select #PMWC17
2:38pm January 24th 2017 via Hootsuite
Butte: Next big data to share? Wuest: Individual connected devices. Filling in lots of gaps that are needed (i.e. mood, depression) #PMWC17
2:29pm January 24th 2017 via Hootsuite
Wuest: Perhaps sharing of clinical data anonymously. #PMWC17
2:24pm January 24th 2017 via Hootsuite
Q: Value of neg. results? Butte: Still an environment of distrust; sharing starts with journal editors, to funding agencies, to law #PMWC17
2:23pm January 24th 2017 via Hootsuite
RT @LincolnNadauld: Three major hurdles of implementing #precisionmedicine: 1) interpreting data, 2) drug procurement, and 3) payment. #PMW…
2:19pm January 24th 2017 via Twitter Web Client
Wuest: Huntington's, diabetes (Pfizer). New biology (multiple myeloma, Cardio), interventions (MS w/Novartis, diabetes w/Sanofi) #PMWC17
2:06pm January 24th 2017 via Hootsuite
Wuest: Combined with optimization, using ensemble of networks using Monte Carlo simulation. Used for biomarker discovery #PMWC17
2:05pm January 24th 2017 via Hootsuite
Wuest: GNS has a Reverse Engineering Forward Simulation. Bayesian stats. Enumerating trillions of network fragments, scored as dist. #PMWC17
2:03pm January 24th 2017 via Hootsuite
Diane Wuest (GNS Healthcare) Unlocking precise knowledge w/in complex data via causal machine learning #PMWC17
1:58pm January 24th 2017 via Hootsuite
Atul Butte’s future map of death and dying, over time. #PMWC17 The purple end-point is sepsis. https://t.co/auofaYgFHv
1:54pm January 24th 2017 via Hootsuite
Butte: Google Maps still can't show all the cars. 2019 - want to show a real-time map of patient. Amazing animation shown. #PMWC17
1:52pm January 24th 2017 via Hootsuite
Butte: Shows more complex pathway - from heart failure to lung disease to sepsis. Or via hypertension to sepsis. #PMWC17
1:51pm January 24th 2017 via Hootsuite
Butte: Wants to build maps on how people get sick and die. Say cirrhosis: alcohol-induced mental disorder, cirrhosis, etc. #PMWC17
1:50pm January 24th 2017 via Hootsuite
Butte: Building a UC-wide data warehouse (15M pts, about 4% of US pop.) Lists many options w/raw clinical data (mobile, transplant) #PMWC17
Butte: 2y at UCSF computional health sciences https://t.co/Zd6DKzYlaA New building in Mission Bay; next: clinical data EHR #PMWC17
1:49pm January 24th 2017 via Hootsuite
Butte: May be a new world: to do virtual clinical trials, testing markers for CDx, much possible with this. #PMWC17
1:47pm January 24th 2017 via Hootsuite
Butte: NuMedii also pushing psoriasis R&D. Next open-data effort: clinical trials. Repository Immport https://t.co/8w27UjFhe4 #PMWC17
Butte: Shows unpublished data on psoriasis. Using a '60's-era diuretic drug (no longer used). Shows triple-stained IHC #PMWC17
1:45pm January 24th 2017 via Hootsuite
Butte:15 mos from computer prediction, NuMedii for SCLC using psych drug and working in mouse now in clin trials #PMWC17
1:43pm January 24th 2017 via Hootsuite
Butte: Shares Carmenta's story startup to acquisition by Progenity https://t.co/4z8uCGc0RL Used public data microarray gene sig's #PMWC17
1:42pm January 24th 2017 via Hootsuite
Butte: Points to this Wired piece w/a cover title 'The End of Science' due to the data deluge https://t.co/NOMkwGtwTt #PMWC17
1:39pm January 24th 2017 via Hootsuite
Atul Butte (UCSF) Driving disease understanding and treatment via a centralized data warehouse #PMWC17
1:37pm January 24th 2017 via Hootsuite
Q: GINA and impact? Mattison: Book (Amazon: https://t.co/Ovq3l0RtPc ) "Lost in Translation" addresses this problem #PMWC17
12:59pm January 24th 2017 via Hootsuite
Mattison: Insight example: spleen transplant, pneumococcal vaccination. 2w vs 3h to find the same patients. #PMWC17
12:56pm January 24th 2017 via Hootsuite
Mattison: A myriad permutations of workflows; improving the process. Little value in retrieving data today; high cost of data entry #PMWC17
12:55pm January 24th 2017 via Hootsuite
Mattison: EHRs is the system 'everybody loves to hate' like cafeteria food. But nobody is advocating going back to paper. (!) #PMWC17
12:54pm January 24th 2017 via Hootsuite
Dilks: Determine where the high-value data is captured within EMRs. What NL processing tech, for valuable data #PMWC17
12:52pm January 24th 2017 via Hootsuite
Q: With EHRs not being efficient, what do you see? (MD Anderson https://t.co/E9GRR49Cdv ) Urban: Link at PoC of benefit to pts #PMWC17
Dilks: Pts quickly find out - this is the way it is going, patients becoming empowered. #PMWC17
12:49pm January 24th 2017 via Hootsuite
Urban: Pts are told 'don't see doctor Google' but of course they do anyway. #PMWC17
RT @DrKhouryCDC: It’s Time for Nationwide Lynch Syndrome Screening. By @HHampel1 https://t.co/bXdCacz1ZX #PMWC17 https://t.co/zou8fnHGwr
12:49pm January 24th 2017 via Twitter Web Client
RT @GuneetWalia: The tech that'll allow BGI & @CompleteGenomic to sequence 100,000 genomes/yr at <$100- DNA nanoball sequencing- Rade
12:48pm January 24th 2017 via Twitter Web Client
RT @GuneetWalia: Drmanac @CompleteGenomic acquired by BGI, shares promising DNA nanoball-based sequencing for #PrecisionMedicine #PMWC17 #N…
12:47pm January 24th 2017 via Twitter Web Client
Diamond: Where the physician was incorrect. Role of consumers? Urban: Parents do request healthy baby testing. #PMWC17
12:44pm January 24th 2017 via Hootsuite
Diamond: Public's thirst for genomic data exceeds the physician's expertise. Ex: pulmonary fibrosis. 'Can I get a genetic test?' #PMWC17
12:43pm January 24th 2017 via Hootsuite
Mattison: Moffit's video about risks/rewards for genomic sequencing - 100% participation. We need to promote informed consent etc #PMWC17
12:42pm January 24th 2017 via Hootsuite
Mattison: (Asks for show of hands who has donated their genome for sequencing) There are real risks for this data, consent #PMWC17
12:41pm January 24th 2017 via Hootsuite
Mattison: Refers to this '16 Fast Company https://t.co/uxtb0sB7ih about BRCA testing and insurance options. #PMWC17
12:40pm January 24th 2017 via Hootsuite
Dilks: What HCA is trying to do - enabling physician w/info, and enabling pts to act on this. #PMWC17
12:34pm January 24th 2017 via Hootsuite
Dilks: With a partner with a strong response, people will learn and start demanding access to tests and trials. Exciting convergence #PMWC17
12:33pm January 24th 2017 via Hootsuite
Mattison: From the public perception standpoint, 'I don't think we're that far away'. #PMWC17
12:32pm January 24th 2017 via Hootsuite
Mattison: What 'tipping point' event for a genetic disorder to justify widespread screening? Sth like sickle-cell and curable? #PMWC17
Dilks: There are reimbursement challenges, grapple with the same problem/issues as others. Tests are ordered; unclear who foots bill #PMWC17
12:29pm January 24th 2017 via Hootsuite
