Patient with a rare disease will get a private meeting with Trump | Stat News https://t.co/dl17rgwU3O
9:51pm February 28th 2017 via Hootsuite
Colorectal cancer rates rising sharply among Gen X and millennials - The Washington Post https://t.co/w1qGTPPBQ0
1:57pm February 28th 2017 via Hootsuite
Enabling Clinical Genomics with Highly Multiplexed and Patient-like Ref Materials Webinar March 1 1PM ET https://t.co/xVpmcE2nhZ @SeraCare
12:35pm February 28th 2017 via Hootsuite
Trisomy Spotted in Chimp | GenomeWeb https://t.co/lXSkX1P3Cs
8:40am February 28th 2017 via Hootsuite
RT @drbachinsky: New program aims to build genetics research capacity in Africa https://t.co/Y2OiSF88QY
8:04am February 28th 2017 via Hootsuite
DIY Gene Editing: Fast, Cheap—and Worrisome - WSJ https://t.co/fIX89SKIDG
7:35pm February 27th 2017 via Hootsuite
When Evidence Says No, but Doctors Say Yes - The Atlantic https://t.co/JqrFHEez1w
5:40pm February 27th 2017 via Hootsuite
A giant neuron found wrapped around entire mouse brain : Nature News https://t.co/rfEkMJNqY0
4:30pm February 27th 2017 via Hootsuite
A CRISPR/Cas9 startup launches on the R&D frontier, working on a one-time fix for Duchenne MD – Endpoints News https://t.co/Dcm1cTrcWu
3:30pm February 27th 2017 via Hootsuite
An epigenetics gold rush: new controls for gene expression : Nature News https://t.co/dNjFF583gE
2:30pm February 27th 2017 via Hootsuite
Going big: Biotech vets blast off with Arrakis on a new journey of RNA exploration – ENDPOINTS NEWS https://t.co/2TWS21bwJw
1:30pm February 27th 2017 via Hootsuite
The genome Aggregation Database (gnomAD) released today | MacArthur Lab https://t.co/TbQ9Pjy0qH
12:25pm February 27th 2017 via Hootsuite
Personalizing Treatment With ctDNA in Prostate Cancer | CURE Magazine https://t.co/Tm3hr5cAdJ
11:25am February 27th 2017 via Hootsuite
MT @DrKhouryCDC: Evidence for population screening for Lynch syndrome? #cancermoonshot https://t.co/N1uKwlBiDs https://t.co/6c3kNDHUIp
10:20am February 27th 2017 via Hootsuite
Study links working remotely to more stress, insomnia | MedicalXpress https://t.co/HTJzO2wjix
9:25am February 27th 2017 via Hootsuite
RT @biorxivpreprint: Short DNA sequence patterns accurately identify broadlyactive human enhancers https://t.co/GqolOCfKjZ #bioRxiv
9:22am February 27th 2017 via Twitter Web Client
Craig Venter: Trying to decode death | Forbes Video https://t.co/AEGzZdz9jf
8:22am February 27th 2017 via Hootsuite
Biologists propose to sequence the DNA of all life on Earth | Science https://t.co/3XMZWaX5P5
12:50pm February 25th 2017 via Hootsuite
Reddit is Being Manipulated By Big Financial Services Companies | Forbes https://t.co/Vn6UTtwNuz Internet shilling = big business
6:15pm February 24th 2017 via Hootsuite
Paweletz: Truth is clinical outcome: validation PFS by tumor, plasma T790M status, response '16 ref https://t.co/zS75h53t8f #tricon
3:48pm February 24th 2017 via Hootsuite
Paweletz: Truth is clinical outcome: validation of plasma T790M vs response rate. PFS by tumor, plasma T790M status #Tricon
3:46pm February 24th 2017 via Hootsuite
Paweletz: Guardant work (n=113), <0.5% sens for EGFR Ex19del, cp to ddPCR. For L858R, consistent data #Tricon
3:44pm February 24th 2017 via Hootsuite
Paweletz: Blinded analysis of EGFR and KRAS w/matched NGS vs ddCPR results. Sens about 0.5%. '15 ref https://t.co/hiJDLqQeR1 #Tricon
3:42pm February 24th 2017 via Hootsuite
Paweletz: Between ddPCR to BEAMing: 92% concordance; ARMS (cobas) about 85% concordance. 'Not that great' #Tricon
3:40pm February 24th 2017 via Hootsuite
Paweletz: Collab w/Clovis (3rd gen TKI), had to be T790M+ cobas test; did BEAMing, did ddPCR. Truth was tissue. #Tricon
3:39pm February 24th 2017 via Hootsuite
Paweletz: Showed data from prospective clin trial ref https://t.co/mHCqarLRiT and prevalence data #Tricon
Paweletz: Uses contrasting, non-overlapping genotypes, to det gold std pos, neg populations. A ref range for each assay can be ID'd #Tricon
3:37pm February 24th 2017 via Hootsuite
Paweletz: Curves of 60,70,80,90% sens; and 99,95,90% spec - need to move to 100% specificity for clinical util #Tricon
3:36pm February 24th 2017 via Hootsuite
Paweletz: 90% sens, 98% specific, prevalence is 2%. 1K pts, 20 will have mut; 18/20 positive, 2 neg. But of 960 negs, 40 will be FPs #Tricon
3:35pm February 24th 2017 via Hootsuite
Paweletz: Validation of a new plasma assay depends 'on your interpretation of truth'. Discussion of specificity needs revisiting #Tricon
3:34pm February 24th 2017 via Hootsuite
Paweletz: Data for two pts from '14 ref EGFR https://t.co/jX1ubaXSp1 ex19del, EGFR T790M and progression #Tricon
3:32pm February 24th 2017 via Hootsuite
Paweletz: 8/44 no followup; 4/44 insufficient. #Tricon
3:30pm February 24th 2017 via Hootsuite
Paweletz: 3rd-line TKI req ctDNA; Clin trial, n=83 eligable, screen fail n=23; of 60 from '10-'15, 12 ongoing, 44 progressed #Tricon
3:29pm February 24th 2017 via Hootsuite
Paweletz: Lung ca is increasingly a disease of targetable driver genes. Emergence of T790M-mut clones is inevitable #Tricon
3:27pm February 24th 2017 via Twitter Web Client
Paweletz: It is a 'tick-tock' cycle of innovation, biology, assays; lung ca is the 'poster child for personalized med' #Tricon
3:26pm February 24th 2017 via Twitter Web Client
Paweletz: They work with Pharma, CLIA dev, partner with biotech for assay dev/validation/licensing. #Tricon
3:25pm February 24th 2017 via Twitter Web Client
Cloud Paweletz (Dana Farber MA) Monitoring cancer through blood #Tricon
3:24pm February 24th 2017 via Twitter Web Client
Thank you to all #Tricon attendees who I met this week - @raindancetech @archerdx @rustyshacklferd @genomenathan @twoporeguys
3:20pm February 24th 2017 via Twitter Web Client
Tam: Looking at 0.5% on @archerdx detection (AF from 0.35 to 1.18%) but 5/8 detected at 0.1% (0.1-0.27%) #Tricon
3:16pm February 24th 2017 via Twitter Web Client
Tam: Plans to use @archerdx molecular-tagged cfDNA technology to look at <1% #Tricon
3:12pm February 24th 2017 via Twitter Web Client
Tam: Titrated Acrometrix controls to 1%, was able to show sensitivity for most mutations. Error bkgd ~.5% #Tricon
3:08pm February 24th 2017 via Twitter Web Client
Tam: Needing to go to NGS, used @iontorrent for small input w/AmpliSeq. Complimentary comments about Ion Chef instrument #Tricon
3:07pm February 24th 2017 via Twitter Web Client
Tam: ddPCR cp to qPCR, shows greater sensitivity (not surprisingly) #Tricon
3:03pm February 24th 2017 via Twitter Web Client
Tam: Asssay sensitivity is directly proportional to amout of input; 20ng = 0.08%; 10ng at 0.17%. Data across multiple genes #Tricon
3:02pm February 24th 2017 via Twitter Web Client
Tam: ddCPR provides higher accuracy and sensitivity for quantification esp for FFPE. At 350ng input (10K copies) can detect to 0.01% #Tricon
3:00pm February 24th 2017 via Twitter Web Client
Tam: Shows longitudinal blood draw and imaging data for n=30 pediatric pts for cobas EGFR v2, ongoing trial #Tricon
2:57pm February 24th 2017 via Twitter Web Client
Tam: Has been responsible for bringing in new technologies; shows data from Bettegowda '14 regarding % by stage. #Tricon
2:55pm February 24th 2017 via Twitter Web Client
Rachel Tam (Genentech CA) Ultra-sensitive mutational analysis in cell-free DNA by digital PCR and NGS technologies #Tricon
2:51pm February 24th 2017 via Twitter Web Client
Dobrovic:dPCR is good, cheap and fast unlike this https://t.co/Uzau4FemWK and can recommend #Tricon
2:49pm February 24th 2017 via Twitter Web Client
Dobrovic: Word about digital PCR and this funny image https://t.co/Uzau4FemWK 'you can only pick 2 of 3', dPCR is good, cheap, and fast
2:48pm February 24th 2017 via Twitter Web Client
