April 2018

The winner of the Crab Trap: Galen Robotics #BHCRForum18 Johns Hopkins - $10K award.

10:13am April 24th 2018 via Twitter Web Client

List of #BHCRForum18 Crab Trap participants https://t.co/PYlUJbvnsn

10:09am April 24th 2018 via Twitter Web Client

RenAlert: #BHCRForum18 Tackling acute kidney injury. 15% of 600K US cardiac surgeries get AKI (perfusion). 2% on dialysis.

9:49am April 24th 2018 via Twitter Web Client

Galen Robotics: #BHCRForum18 Improved dexterity, can put in virtual safety features, can be used for training. Market: $21B, 21% 5y CAGR

9:41am April 24th 2018 via Twitter Web Client

Galen Robotics: #BHCRForum18 Only 'cooperatively controlled robot'. Accomodates standard instruments (endoscope). Shows video.

9:39am April 24th 2018 via Twitter Web Client

Galen Robotics: #BHCRForum18 'rockstar surgeons' are rare, limited supply. Existing robotic systems are unaffordable, unflexible

9:38am April 24th 2018 via Twitter Web Client

Galen Robotics: #BHCRForum18 Making critical surgeries safer. Min invasive surgery has benefits, but long tools to reach a small spot

9:36am April 24th 2018 via Twitter Web Client

Cellth Systems: #BHCRForum18 Involved with 2 CTC co's now. Also working with a large pharma.

9:33am April 24th 2018 via Twitter Web Client

Q: Commercial model? Cellth Systems: #BHCRForum18 Decentralized approach: product + software. Agnostic to users. >40 co's on CTC enrichme

9:33am April 24th 2018 via Twitter Web Client

Cellth Systems: #BHCRForum18 Seeking $2M to expand dataset, software, and GMP setup.

9:30am April 24th 2018 via Twitter Web Client

Cellth Systems: #BHCRForum18 Shows movie. Chip, use existing microscopy, and software. Shows analysis, drug-test, data

9:29am April 24th 2018 via Twitter Web Client

Cellth Systems: #BHCRForum18 PEM (polyelectrolyte membrane) on slide; lipid tethers on PEMs, immob. Drug flows through channel

9:28am April 24th 2018 via Twitter Web Client

Cellth Systems: #BHCRForum18 Pt-spec result in 1h; no cell-growth req. Growth models: glass or plastic adherence req'd.

9:27am April 24th 2018 via Twitter Web Client

Cellth Systems: #BHCRForum18 Primary cell models (PDX), results in 2h vs 6w or 6mo. $1B market prior to FDA. 90% margin, disp device

9:24am April 24th 2018 via Twitter Web Client

Cellth Systems: #BHCRForum18 Pt spec drug selection w/tetherscreen: a pers med device for ideal Rx drug for cancer pts

9:24am April 24th 2018 via Twitter Web Client

Q: Addressable market? Final use? Algometrix: #BHCRForum18 Want to be in every clinical pain trial. Hosp reimb. needed, several years out.

9:22am April 24th 2018 via Twitter Web Client

Q: Sales model? Algometrix: #BHCRForum18 Want dist. channel, existing medical device co's. MSL's needed for device/pain.

9:20am April 24th 2018 via Twitter Web Client

Algometrix: #BHCRForum18 Purusing fast-track FDA; expected annual license model. Area collabs including Children's Nat'l, NIH, GWU

9:19am April 24th 2018 via Twitter Web Client

Algometrix: #BHCRForum18 Shows baseline, monitor on finger, shows data of pt on opiods, at different freq. Diff Rx, shows effect

9:16am April 24th 2018 via Twitter Web Client

Algometrix: #BHCRForum18 Pain is subjective; Nociometer determine pain type, intensity. Eyecup device, box. Pupillary light reflex

9:14am April 24th 2018 via Twitter Web Client

Crab Trap: 5 startup forum 7min #BHCRForum18 Shaun Grady (VP AstraZeneca), Sara Nayeem (New Enterprise Assoc), John Rubin (JP Morgan)...

9:11am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18 Some risk - another org uses data to file regulatory; another org files a 'use' patent.

9:05am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18 Chemsitry plans are all in public, monthly presentations, B-I is telling abt their internal (killed) program

9:04am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18 Started drug disc, crystal structure solved 10y ago. All parties agree to public domain. $3.5M raised.

9:02am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18 Going after inoperable diffuse intrinsic pontine glioma; fatal, mut in H27M histone H3, some ALK2 kinase (ACVR1)

9:01am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18 M4K is owned by arm's length Charitable Trust, committed to making meds affordable

9:01am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18 Restriction of M4K is 'use of pre-clin and clin data for reg filings, preserving exclusive marketing rights'

9:00am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18 To disc, develop affordable medicines for rare childhood cancers. Patents enable sharing.

8:59am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18 Orphan drugs may extend another 2y; EU 10+, CAN 8y, JP 8y. Started M4K pharma to coord https://t.co/OkOsCht1vF

8:58am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18 Another way to protect your market: the regulatory pathway. 20y patent may only have 5y of data exclusivity

8:56am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18 Deciding to do drug disc 'in the open', taking it all the way to market. Lists criticisms: $, how to protect?

8:55am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18 Pharma donated probe program - eLife ref '18 https://t.co/LDs1Urf4zY pre-competitive sharing

8:54am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18 Points to this commentary '09 ref https://t.co/O2Eq0MLEYl (Ironic: Nature Chem Bio is paywalled.)

8:51am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18 Open data, open publishing, materials and knowledge avail w/o restriction to anyone. 'No deals', no pref access

8:50am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18 'Open science is the most efficient' - started in '04; Wellcome, Gates Found. 'SGC scientists never file patents'

8:49am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18 Inefficiencies - "25 cents or less returned for every dollar spent". Drug disc - illustr. cost of this.

8:48am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18 Ranking from Global vs Canadian science in '16: look identical. Working on the same kinases...

8:45am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18 Medicines are not affordable; 'redundancy is a signif. cause'. 500 kinases; shown ranked by popularity

8:44am April 24th 2018 via Twitter Web Client

Edwards: #BHCRForum18>$250B is invested yearly in biomed res. We still don't even understand molecular mechanisms, let alone Rx strategy

8:43am April 24th 2018 via Twitter Web Client

Aled Edwards (Structural Genomics Consortium Univ Toronto CA) Creating companies from an open science ecosystem #BHCRForum18

8:41am April 24th 2018 via Twitter Web Client

Glad to be here at #BHCRForum18 for a second day. Agenda here: https://t.co/JbdnT5oKVo Crab Trap startup competition later

8:39am April 24th 2018 via Twitter Web Client

Research reveals stronger people (measured by handgrip) have healthier brains | Univ Manchester UK https://t.co/uYBRjMqGHv

9:35pm April 23rd 2018 via Hootsuite

NuProbe Closes $11M Series A Round | GenomeWeb https://t.co/9G99r8hJ1T

9:25pm April 23rd 2018 via Hootsuite

Philips, Navican Look to Integrate Genomics, Pathology Data to Deliver Precision Oncology | GenomeWeb $ https://t.co/emTWdFMLaq

8:20pm April 23rd 2018 via Hootsuite