Eres: #ASHG18 Comparative gene regulation in non-human primates - diff exp. Shows many studies - not sufficient on the gene exp level.
11:33am October 20th 2018 via Hootsuite Inc.
Good morning #ASHG18 - Investigating 3D Genome Structure. Ittai Eres (Univ Chicago) Reorganization of 3D genome str… https://t.co/navEXD7BA1
11:32am October 20th 2018 via Hootsuite Inc.
RT @Bhoomiee: Data showing low precision in measurements, ease your woes with #FridayFeeling #Copied @palomaperezbel1 please see!! https://…
9:12am October 20th 2018 via Buffer
RT @colinhillucc: Is it time to stop measuring, and put the ‘ology’ back into microbiome research? https://t.co/28jpRGZdlG #behindthepaper
8:08am October 20th 2018 via Buffer
At #ASHG18, Singlera Genomics Presents Data on Cell-Free DNA Methylation Test for Early Cancer Detection | GenomeWe… https://t.co/Nn8hIKNlpc
12:31am October 19th 2018 via Buffer
A LOT of receptions to join in at the Hilton Bayfront at@#ASHG18! Join @singlerinc in Salon A/B https://t.co/iv8UczRmBN
9:30pm October 18th 2018 via Hootsuite Inc.
All at #ASHG18 are welcome to attend a joint UCSD @singlerainc reception at the Hilton Bayside Hotel (past Hall H t… https://t.co/yEHufTBisX
9:09pm October 18th 2018 via Hootsuite Inc.
@singlerainc announces at #ASHG18 the results of a 10-year, 120,000-participant longitudinal study, where cancer co… https://t.co/GLTDovKQES
8:27pm October 18th 2018 via Hootsuite Inc.
@singlerainc announces at #ASHG18 the results of a 10-year, 120,000-participant longitudinal study, where cancer co… https://t.co/APPoKkLnoN
6:09pm October 18th 2018 via Hootsuite Inc.
#ASHG18 #earlydetection @singlerainc announces early-detection of Colorectal Cancer (CRC) and even Advanced Adenoma https://t.co/3TlBytVTlf
3:24pm October 18th 2018 via Hootsuite Inc.
Gore #ASHG18 Now a prospective study is needed, to intervene to change pt outcomes. A study they hope to do in the… https://t.co/lYcV14RpiN
12:59pm October 18th 2018 via Hootsuite Inc.
Gore #ASHG18 Poster yesterday, booth 445. Concludes: power of methylation haplotypes in asymptomatic patients. Pote… https://t.co/0UFw4zPere
12:58pm October 18th 2018 via Hootsuite Inc.
Gore #ASHG18 We don't think we are predicting cancer; we think we are just picking up the signals of cancer already… https://t.co/heUEar6QjS
12:57pm October 18th 2018 via Hootsuite Inc.
Gore #ASHG18 100% sens in CRC, liver. Pre-diagnosis: found in asymptomatic indiv's up to 4y before conventional dx (!!)
Gore #ASHG18 Divided 30% into training set, locked the model, looked at 837 (70%). 5 types of cancer. CRC, esophage… https://t.co/ApKKszdHXg
12:56pm October 18th 2018 via Hootsuite Inc.
Gore #ASHG18 Looking for haplotypes means looking for patterns, rather than 'individual averages'. Spec methylation signals in cis.
12:55pm October 18th 2018 via Hootsuite Inc.
Gore #ASHG18 Targeted methylation method that maximizes yield; also unique analysis of haplotypes. Mixture of tumor and wt molecules.
Gore #ASHG18 676 healthy: matched by age, sex, followed up for 5y. 1,193 samples analyzed by PanSeer assay. Paper c… https://t.co/neNcsrRLlJ
12:54pm October 18th 2018 via Hootsuite Inc.
Gore #ASHG18 The 358 post-dx were from biobanked samples, same collection and storage.
12:53pm October 18th 2018 via Hootsuite Inc.
Gore #ASHG18 Given physicals, 575 were dx w/cancer within 4y of first sample collection. 358 post-dx; 159 pre-dx; 676 healthy
12:52pm October 18th 2018 via Hootsuite Inc.
Gore #ASHG18 Case control studies won't do it. Wang et al 09 https://t.co/pdLcnfWhLS 120K people, monitored for 10y… https://t.co/0WxR49GzNB
12:51pm October 18th 2018 via Hootsuite Inc.
Gore #ASHG18 But a longitudinal study is needed to show early detection. The real way to change mortality. Move the time point forward
12:50pm October 18th 2018 via Hootsuite Inc.
Gore #ASHG18 Tumor-like behavior - a similar methylation profile. Shows JHU, GRAIL results: participants were already diagnosed.
Gore #ASHG18 ctDNA methylation 'is a promising marker'. Looking at the epigenome downstream of DNA mutation: not on… https://t.co/Ub9Lib1bkc
12:49pm October 18th 2018 via Hootsuite Inc.
Gore #ASHG18 Early detection of cancer 'incredibly impt' - 9/10 pts survive CRC 5y. Late - only 2/10 make it 5. Nov… https://t.co/XubpXhbFqr
12:47pm October 18th 2018 via Hootsuite Inc.
Athurva Gore (Singlera Genomics) #ASHG18 Circulating tumor DNA methylation haplotypes in plasma can detect cancer f… https://t.co/os66vjwYRA
12:45pm October 18th 2018 via Hootsuite Inc.
LaCroix #ASHG18 Method STRetch '18 https://t.co/7xKzlGqIlX decoy repeat sequence to help analysis
12:39pm October 18th 2018 via Hootsuite Inc.
LaCroix #ASHG18 300 to 2500 larger than wt size bands: next whether it was a (GGC)-repeat.
12:38pm October 18th 2018 via Hootsuite Inc.
LaCroix #ASHG18 'We traveled back in time a few decades and did Southern Blot analysis' - due to repeat expansion s… https://t.co/d71mCmfvyu
12:37pm October 18th 2018 via Hootsuite Inc.
LaCroix #ASHG18 Suspected Exon 1 aberrant methylation. Explains bisulfite seq; found 48 CpG sites in Exon 1 were hy… https://t.co/mHplMpsZin
12:34pm October 18th 2018 via Hootsuite Inc.
LaCroix #ASHG18 A rare disorder, applied WES, targeted, microarray for CNA, Sanger. 2 probands, 2 vars; 1 proband w… https://t.co/9QlwirHTTe
12:33pm October 18th 2018 via Hootsuite Inc.
Amy LaCroix (Univ WA) #ASHG18 Promoter GGX repeat expansion and exon 1 methyl of XYLT1 in Baratela-Scott syndrome
12:31pm October 18th 2018 via Hootsuite Inc.
van den Oord #ASHG18 Pts with BK virus and UTI have varying white cell content. Different bacterial cell types can… https://t.co/BI1F5CvUog
12:26pm October 18th 2018 via Hootsuite Inc.
Cheng #ASHG18 Shows PCA overlaid with tissue clusters. Kidney contribution correlate w/donor fraction. '17 ref https://t.co/b6bKUh7E43
12:24pm October 18th 2018 via Hootsuite Inc.
Cheng #ASHG18 did ss WGBS (2-5x coverage) from kidney transplant pts. n= ~50. ssDNA: urinary cfDNA is short, degraded, damaged.
12:21pm October 18th 2018 via Hootsuite Inc.
Cheng #ASHG18 Now WGBS on urinary cfDNA; 19K kidney transplants/y; 30% dev BK polyomavirus reactivation; 75% dev UTIs.
Cheng #ASHG18 Shows results from 110 ref materials, and PCA plots showing grouping at organ and cell-type levels.
12:20pm October 18th 2018 via Hootsuite Inc.
Cheng #ASHG18 Metagenomic assay informing host response - tissue-spec methylation markers, to help det where infectious site occurs
12:19pm October 18th 2018 via Hootsuite Inc.
Cheng #ASHG18 Half-life of cfDNA is ~30min. Using urinary cfDNA to look for UTI. '18 ref https://t.co/8fi9bekhqZ 'A versatile analyte'
12:18pm October 18th 2018 via Hootsuite Inc.
Alex Cheng (Cornell) #ASHG18 Distinguishing inf from inf disease using methylation marks comprised within cell-free DNA
12:17pm October 18th 2018 via Hootsuite Inc.
van den Oord #ASHG18 Different mech - current vs cumulative; substantial overlap with WAS, other MWAS of health outcomes
12:15pm October 18th 2018 via Hootsuite Inc.
van den Oord #ASHG18 Method used when many more predictors than effects. Concl: T-cells, granulocytes methylome 'substantial impact'.
van den Oord #ASHG18 Many findings 'significant' - their approach for methylation biomarkers and prediction algorit… https://t.co/RkfypoVBOc
12:13pm October 18th 2018 via Hootsuite Inc.
van den Oord #ASHG18 Have to look at spec celltypes in blood; Tool RaMWAS '18 ref https://t.co/KMy6BULHoE
12:07pm October 18th 2018 via Hootsuite Inc.
van den Oord #ASHG18 Covers ~94% of WGS. Only 5-10% of reagent cost, 15x faster, methylome-wide at cost of arrays.
12:06pm October 18th 2018 via Hootsuite Inc.
van den Oord #ASHG18 Method - optimized MBD-seq (methyl-binding protein). Shows chart w/comparison with WG-Bisulfite seq.
12:05pm October 18th 2018 via Hootsuite Inc.
van den Oord #ASHG18 Longitudinal study for 25y, from childhood on. The methylome - trauma in past 3 mos. Cumulativ… https://t.co/6Ph5kcyQPc
12:03pm October 18th 2018 via Hootsuite Inc.
#ASHG18 Edwin van den Oord (VCU) Dev methylomics of childhood trauma and its health consequences
12:02pm October 18th 2018 via Hootsuite Inc.
For those at #ASHG18, this will be presented at 945am today in Room 6C https://t.co/xdNb3Rg4RW
11:57am October 18th 2018 via Hootsuite Inc.
RT @ceccerslike: "Detecting cancer four years before conventional diagnosis" https://t.co/KisKfFL5Ye by @DaleYuzuki on @LinkedIn
11:56am October 18th 2018 via Hootsuite Inc.
