MCED Panel #AACR23 Castle pt 2: imaging is also uneven - as far as all organs go. Bradbury: Tumor of origin signal:… https://t.co/3m0eweuarj
1:18pm April 18th 2023 via Twitter Web App
MCED Panel #AACR23 Castle: About SOC, some SOC tests prevent cancers, e.g. colorectal cancer and cervical cancer sc… https://t.co/QYV1ZdXaM1
1:17pm April 18th 2023 via Twitter Web App
MCED Panel #AACR23 Diaz: These are high-risk tests. "It is more like a potential drug." You have to consider the ha… https://t.co/j4zP8MSogJ
1:14pm April 18th 2023 via Twitter Web App
MCED Panel #AACR23 SOC screenings - many individuals are not current. Wood: Had focus groups, clinical trials needs… https://t.co/40zxp0CyvG
1:13pm April 18th 2023 via Twitter Web App
MCED Panel discussion #AACR23 add'l participants: Luis Diaz (Memorial Sloan Kettering NY), Kim Newcomer (Colorectal… https://t.co/b8EuwQXeEJ
1:10pm April 18th 2023 via Twitter Web App
Bradbury #AACR23 For her BRCA carrier patients, have been waiting for something like this, but 'not ready now, hope… https://t.co/d56IgVIbz6
1:08pm April 18th 2023 via Twitter Web App
Bradbury #AACR23 Pt discussion - autonomy, beneficience, justice/equity. HCP's are bound by beneficience, we don't… https://t.co/kvL6UO60Ag
1:06pm April 18th 2023 via Twitter Web App
Bradbury #AACR23 3. Not clear if the tumor of origin data is accurate, very important. 4. Diagnostic odyssey and th… https://t.co/iyD1Dk68ZQ
1:05pm April 18th 2023 via Twitter Web App
Bradbury #AACR23 Shows figure in first reference - two more tests PanSeek and Burning Rock. Stage shifting is not e… https://t.co/qgkrZLmbzZ
1:04pm April 18th 2023 via Twitter Web App
Bradbury #AACR23 For a new drug: "wait until FDA approval"; but LDTs are different. Presume the test has all the sa… https://t.co/wceTuFwSOA
1:01pm April 18th 2023 via Twitter Web App
Bradbury #AACR23 Great promise - so simple. "Detect cancer early when it can be cured!" Her patients in a high-risk… https://t.co/4CwjCq7g3P
12:59pm April 18th 2023 via Twitter Web App
Angela Bradbury (Univ Penn PA) #AACR23 MCED assays: early detection or early distraction. Effectiveness and clinica… https://t.co/OF741omCzE
12:58pm April 18th 2023 via Twitter Web App
Wood #AACR23 Another 1000 cases from underrepresented groups is planned.
12:56pm April 18th 2023 via Twitter Web App
Wood #AACR23 Called A212102, eligability 40-75, controls no prior cancer, cases no prior treatment. Looking at 18 d… https://t.co/gZ0pLbN0BD
Wood #AACR23 These pts are generally asymptomatic; how to follow-up. Despite lack of evidence for clin utility, one… https://t.co/emD0oya1SR
12:54pm April 18th 2023 via Twitter Web App
Wood #AACR23 23 new cancers discovered; 9/23 39% Stage I-II. Long list of important considerations: Testing; who sh… https://t.co/1qjB0NmBVF
12:52pm April 18th 2023 via Twitter Web App
Wood #AACR23 Grail's Pathfinder study. 6200 participants, 15 institutions. Age >50, history of cancer or smoking, a… https://t.co/dnewL8m
12:50pm April 18th 2023 via Twitter Web App
Wood #AACR23 Found only 26 cancers, 1/2 were early stage. PPV of about 40%, sens 27%, spec of >99%. 2020 Science re… https://t.co/2uGlrXO
12:48pm April 18th 2023 via Twitter Web App
Wood #AACR23 Lists two companies - GRAIL's Galleri and THRIVE's CancerSEEK, with prospective data. CancerSEEK: PCR… https://t.co/Xi7N6CDUBg
12:47pm April 18th 2023 via Twitter Web App
Wood #AACR23 All assoc'd with high FP, low PPV, problems of overdiagnosis and overtreatment. "71% of cancer deaths… https://t.co/LxPWnstYpx
12:45pm April 18th 2023 via Twitter Web App
Marie Wood (Univ Colorado CO) #AACR23 Promise and future direction for multicancer detection assays. A bit about wh… https://t.co/HBLTFhb7zX
12:44pm April 18th 2023 via Twitter Web App
Castle #AACR23 Primary endpts: all cancer deaths measured; death rates from MCED 1 and 2. Composing a reveal/concea… https://t.co/3ib20iyozl
12:43pm April 18th 2023 via Twitter Web App
Castle #AACR23 Vanguard: 8K persons per arm control, MCD1 and 2; all arms offered SOC cancer screenings. Objectives… https://t.co/oMWmX2vyUF
12:41pm April 18th 2023 via Twitter Web App
Castle #AACR23 Will see 'cancers we have never seen before'; lunar landing analogy: the impact on technologies that… https://t.co/KptToRNWGb
12:39pm April 18th 2023 via Twitter Web App
Castle #AACR23 From basic science to real-world evidence. Has a reference set for analytical validation, Vanguard/M… https://t.co/J6t8UhDkR3
12:38pm April 18th 2023 via Twitter Web App
Regulatory science session #AACR23 Multi-cancer early detection (MCED) assays: early detection versus early distrac… https://t.co/61HT1i371P
12:36pm April 18th 2023 via Twitter Web App
Longo #AACR23 Q: Ketone bodies in blood? A: By day 3 they go up. But diet designed to not raise them too high.
11:36am April 18th 2023 via Twitter Web App
Longo #AACR23 Q: Do you need to control for corticosteriods as an anti-emetic? A: Succeeded in Europe to remove the… https://t.co/i2zrDTLq0w
Longo #AACR23 Q: What about chronic cancer pts? A: About to publish two papers; in CLL, some pts have been doing th… https://t.co/Nwky5kxt44
11:35am April 18th 2023 via Twitter Web App
Longo #AACR23 Q: Is it fasting, or reducing caloric intake? A: No, the composition matters a lot. Can increase prot… https://t.co/IQcJKnurJh
11:32am April 18th 2023 via Twitter Web App
Longo #AACR23 FMD creates a difficult environment - b/c of many nutrients are lower. Lower ferritin, affecting immu… https://t.co/bTtWWhcmpV
11:29am April 18th 2023 via Twitter Web App
Longo #AACR23 scRNA analysis looks at increase in early exhausted effector T-cells, a reversible state. FMD cycles… https://t.co/XoFIAXq72Y
11:25am April 18th 2023 via Twitter Web App
Longo #AACR23 Short-term starvation sensitizes lung tumors to PD-1 blockade '21 Nature Cancer https://t.co/RgAtTTjqK3
11:22am April 18th 2023 via Twitter Web App
Longo #AACR23 Hormone therapy + FMD cycles in MCF7 mice '20 Nature https://t.co/8Se9QcfePK Also did after treatment… https://t.co/6ZdE3B5oM2
11:20am April 18th 2023 via Twitter Web App
Longo #AACR23 Showed in '21 ref https://t.co/4N4W9kO2cQ Fasting / FMD reverts late-stage tumor progression in SUM15… https://t.co/HNUoOGqEYW
11:19am April 18th 2023 via Twitter Web App
Longo #AACR23 Only the combination of chemotherapy and fasting promotes cancer-free survival in mice. 2-3 day fasti… https://t.co/9y1VHkNRPd
11:16am April 18th 2023 via Twitter Web App
Longo #AACR23 In mice - Normal diet die from chemo, short-term fast survive. Water-only - hard to adhere to, develo… https://t.co/g6AuvVRGHO
11:14am April 18th 2023 via Twitter Web App
Valter Longo (Univ Southern Calif CA) #AACR23 Fasting mimicking diet cycles in cancer treatment. Works on aging and… https://t.co/EZ0jyQsWjr
11:13am April 18th 2023 via Twitter Web App
Kwong #AACR23 Showed response to alpha-PD1 blockade is mediated by GzmB+ CD8+ TILs. 2022 Ref… https://t.co/DjisDeiP5F
10:57am April 18th 2023 via Twitter Web App
Kwong #AACR23 Appears in urine, small fragments detected via MS. Can build classifiers from there. Application: T-c… https://t.co/CNQWd6t6BL
10:54am April 18th 2023 via Twitter Web App
Kwong #AACR23 And can consider multiplex the synthetic sensors - whether dysregulated protease activity, enzymatic… https://t.co/o2QBOclHlI
10:50am April 18th 2023 via Twitter Web App
Kwong #AACR23 Enzymatic, small-molecule, vector-based, mammalian-cell based, bacterial cell based sensors available… https://t.co/9E8DWlIzyb
10:48am April 18th 2023 via Twitter Web App
Gabe Kwong (Emory Univ GA) Urinary assessment of response and resisatance to checkpoint blockade immunotherapy via… https://t.co/xVzECT6Cd0
10:47am April 18th 2023 via Twitter Web App
Heller #AACR23 Benefits - known biomarkers not req'd, can test multiple hypotheses, can improve with add'l samples… https://t.co/jn5VeMRFb5
10:37am April 18th 2023 via Twitter Web App
Heller #AACR23 Known serum biomarkers drive part of the prediction; compared to increasing CA125 detected well, HE4… https://t.co/vTTIZRwCmd
10:34am April 18th 2023 via Twitter Web App
Heller #AACR23 PCA didn't show much, used ML and changed up sensors, got 6 sensors with 4 features (24 in all) got… https://t.co/ugSqBwU36n
10:32am April 18th 2023 via Twitter Web App
Heller #AACR23 Wraps nanotube in DNA, uses quantum defect to bond chemical moieties. n-295 pt samples. Evaluated em… https://t.co/Q3QsThK6lZ
10:30am April 18th 2023 via Twitter Web App
Heller #AACR23 Modifications can modify what they detect - pH, different binders. Introduced to serum, get emission… https://t.co/5GhDwE6f75
10:28am April 18th 2023 via Twitter Web App
Heller #AACR23 Carbon nanotubes: metallic ones are fluorescent. Shows different wavelengths, 900 to 1300 nm (tissue… https://t.co/4LAjHARRbl
10:26am April 18th 2023 via Twitter Web App
Heller #AACR23 The brain can detect T's of smells from only 400 sensors. Thus 'whole disease fingerprinting'. The '… https://t.co/82BtWfUQys
10:25am April 18th 2023 via Twitter Web App
