Error, alignment, and the myth of the complete genome

13 years ago

The myth of the complete genome is something that is not commonly known to active observers of genomic technologies. (The…

Oxford Nanopore, the first nanopore-based sequencing technology

13 years ago

Oxford Nanopore, based in Oxford U.K., made a remarkable announcement that surprised many in February's AGBT meeting in Marco Island.…

What’s so special about single molecule sequencing?

13 years ago

A few days ago I reviewed in brief the history of Helicos Biosciences (HCLS), a company that held out the…

QIAGEN and NGS – the Intelligent Bio-Systems Acquisition

13 years ago

Recently I was asked what Roche would purchase when they said publicly that they "would not revisit Illumina, and will…

Helicos Single Molecule Sequencing – A Pioneer

13 years ago

The next-generation sequencing market continues its downward trajectory - routinely violating Moore's Law by an estimated 3x, the cost per…

What’s so special about a $1,000 genome?

13 years ago

In every technological revolution, there is a first seminal breakthrough, a burst of commercial activity from many individual companies, and…

Complete Genomics and the Whole Genome Sequencing market

13 years ago

Complete Genomics is a startup business founded upon a particular idea - that the whole genome sequencing of human individuals…

Next Generation Sequencing – Sequencing by Ligation

13 years ago

If you've been following thus far, we've covered sequencing by pyrophosphate detection, sequencing by reversible terminators, and now we have…

Next Generation Sequencing – Sequencing by Reversible Terminators

13 years ago

As mentioned previously, there are three main methods of sequencing, the first being the pyrophosphate detection approach, and here is…

Next Generation Sequencing – Sequencing by Pyrophosphate Release

13 years ago

After preparation of the library (and careful quantitation) and preparation of the amplified template comes the main event: the sequencing…