In a large meta-analysis, circulating protein levels of severe COVID patients along with many thousands of genomic datasets leads to an exciting discovery: a mutation in a gene called FAS that turns it into a non-membrane-bound, soluble form, interrupting normal immune function. In addition, an on-market chemotherapeutic drug has been shown to lower soluble FAS, … Read more
A new post that presents the concepts underlying combining 30 years of genomic research with the proteins in circulation to determine not only disease risk but the cause of disease.
With a robust collection of 500,000 individuals, the UK Biobank will succeed in its mission to study the determinants of disease through genetics and proteomics combined with extensive electronic health records and ongoing assessments What the UK Biobank is and its current status The UK Biobank (abbreviated UKB or UKBB) began in 2006 as a … Read more
An economical and scalable benchtop instrument bringing multiplex protein assays to individual laboratories or centralized core facilities The Olink original offering: 96-plex on the Fluidigm Biomark Olink started its commercial laboratory in the Boston area in 2016, based upon the Proximity Extension Assay technology and method published in a 2014 PLoS One paper entitled “Homogenous … Read more