Cancer

Single-cell companies Mission Bio and Celsee Inc. at American Association for Cancer Research 2019 #AACR19

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Mission Bio's Tapestri system

Mission Bio’s single-cell targeted DNA enrichment by multiplex PCR shows additional capabilities they are developing, and Celsee’s CTC enrichment also claims sc-RNA-Seq and sci-ATAC-seq potential In 2015 at the AACR conference in Philadelphia PA I noticed a poster that looked eerily familiar – the formation of water-in-oil droplets (“emulsions”) via a microfluidic device, reminiscent of … Read more

Miltenyi MACSima Imaging and Arima Genomics debut at the American Association for Cancer Research 2019 #AACR19

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High-content imaging continues to be a theme, and will Hi-C become a popular research tool? Yesterday Akoya Biosciences showed a system that could do 50 fluorescent markers for high-content imaging of tissue samples, with a separate stage the mounts on an existing fluorescent microscope. Nanostring also celebrated the GeoMx launch complete with an evening launch … Read more

The early days of spatial genomics at #AGBT19

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Illustration of Nanostring's GeoMx Digital Spatial Profiling technology

At #AGBT19 there is a palpable movement from dissociated single cells to single cells in situ Every year at the Advances of Genome Biology and Technology you can see what the future holds. When long-read sequencing was introduced in 2011, people here at AGBT19 are still talking about that Pacific Biosciences fireworks display on the … Read more

Looking for new circulating biomarker signals with new technology

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Here at the American Society for Human Genetics (#ASHG18) it has been several years since I’ve attended. The exhibit hall is as large as ever, plenty of new firms in DTC (Direct To Consumer) genomics, bioinformatics, and other technical feats are out in full-force. The new Singlera website is now live. What has been fun … Read more

Detecting cancer four years before conventional diagnosis

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Announcing a big move for Dale affecting his family, his employer, his colleagues, and his friends Note: This article originally appeared on LinkedIn. The magic wand of early detection Several years ago at a meeting with sales management, someone asked a provocative question: “If you had a magic wand, what would you ask for?” If … Read more

Observations from American Association for Cancer Research 2018 #AACR18

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It is something of a tradition for me to give some reviews of notable presentations from past AACR conferences. For example, here’s one that I did while at SeraCare for #AACR16, here’s one from #AACR15, and another one here from #AACR14. (Briefly looking for highlights from 2017, well it looks like something is remiss!) I’ve had … Read more

NanoString’s Hyb & Seq Single Molecule Sequencer at #AGBT18

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Background Back in 1989 in Belgrade Yugoslavia, Radoje Drmanac had an idea that would shape the next decade of genetic analysis, which was being able to sequence megabases of DNA information by a collection of 11-mers to 20-mers. Doing the mathematical calculations, this paper lays out what kind of DNA oligonucleotides would be needed to … Read more

NanoString’s Digital Spatial Profiling Microscope at #AGBT18

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Now that another year has passed it is great to see the NanoString Digital Spatial profiling microscope near its commercial launch. The platform will be in early access to select customers in the fourth quarter of 2018, and full commercial launch in the first half of 2019. For those interested in accessing the technology, they … Read more

Ion GeneStudio S5: The latest iteration of Thermo Fisher Scientific NGS

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With the beginning of the influential JP Morgan Healthcare investor conference this week in San Francisco, you can expect an avalanche of news from companies large and small regarding all things therapuetic and diagnostic. With an official count of about 9,000 attendees, there are many more in San Francisco who are there to have other … Read more

Thoughts from the Association of Molecular Pathology conference #AMP2017

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John Iafrede (Massachusetts General Hospital, MA) “There is a tidal wave of cell-free approaches; little performance testing; and the big question is who is going to pay for it.” This year’s Assocation for Molecular Pathology was held in Salt Lake City, Utah from November 15-18, 2017. (You can find the 2017 program and abstract here.) … Read more

Pillar Biosciences at Association for Molecular Pathology #AMP2017

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While at the Association for Molecular Pathology in Salt Lake City Utah, I was able to interview Gang Song CEO of Pillar Biosciences to ask him about the challenges in the clinical laboratory that Pillar is tackling, about the basics of SLIMamp technology, and recent news. Check it out! #AMP2017

Preview of Association for Molecular Pathology 2017 #AMP2017

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With over 2000 clinical laboratory professionals in molecular diagnostics and pathology, plenty of technology and offerings on display. This year the Association for Molecular Pathology takes place in Salt Lake City Utah, and promises an abundance of new technology as well as the new accompanying science around diagnostic testing. Since this is a molecular pathology … Read more