With Singular Genomics announcing the new G4 system at the end of 2021, and Element Biosciences announcing the AVITI system in March 2022, here is a look at the existing state-of-the-art systems in a single graphic After spending some time in Los Angeles this week visiting a few existing and potential customers for Olink Proteomics, … Read more
A new approach to next-generation sequencing, a little-known company unwraps an instrument that competes directly with the Illumina NextSeq 2000 with a third more of the throughput at half the consumables price For a technology that started in 2005 with the first 454 / Roche FLX next-generation sequencing (NGS) platform, followed in 2007 with the … Read more
A direct-to-consumer COVID-19 test available via Amazon with a convenient saliva sample-type and fast central-laboratory processing The current environment for this third (or is it fourth) wave of COVID-19 SARS-CoV-2 infections is reaching new records. The first week of January 2021 is seeing a 7-day moving average of cases above 234,000 per day (the prior … Read more
Mission Bio’s single-cell targeted DNA enrichment by multiplex PCR shows additional capabilities they are developing, and Celsee’s CTC enrichment also claims sc-RNA-Seq and sci-ATAC-seq potential In 2015 at the AACR conference in Philadelphia PA I noticed a poster that looked eerily familiar – the formation of water-in-oil droplets (“emulsions”) via a microfluidic device, reminiscent of … Read more
High-content imaging continues to be a theme, and will Hi-C become a popular research tool? Yesterday Akoya Biosciences showed a system that could do 50 fluorescent markers for high-content imaging of tissue samples, with a separate stage the mounts on an existing fluorescent microscope. Nanostring also celebrated the GeoMx launch complete with an evening launch … Read more
Akoya Biosciences offers 50+ protein markers along with existing Phenoptics offering, while Berkeley Lights has a unique single-cell, live-cell analysis platform Every year the American Association for Cancer Research conference is a major conference for major product announcements and new companies to test the cancer research market. And while walking around the exhibit floor, you … Read more
Cardea Bio Inc. and Nanosens Innovations Inc., Keck Graduate Institute and UC Berkeley detect two deleted DMD exons in 15 minutes down to 1.7 fM sensitivity We are currently living in an exciting time in molecular diagnostics, as the fields of chemical fluorescence, optics, electronics, microfluidics, biochemistry, genomics and nanofabrication intersect and produce surprising synergies. … Read more
Automation may seem a straightforward task, for those who have not tackled it before As an attendee of Advances in Genome Biology and Technology (#AGBT19) there are plenty of new things to check out, and while it may not be as cutting edge as spatial genomics or mRNA isoform discovery from long single-molecule reads, liquid … Read more
Single-cell isoforms from long-reads take the stage at the Advances for Genome Biology and Technology, along with structural variation and better reference genomes. Underlying all these advances is better long-read technology from Pacific Biosciences and Oxford Nanopore. Thinking a little further about the overarching theme of this year’s Advances in Genome Biology and Technology conference … Read more
At #AGBT19 there is a palpable movement from dissociated single cells to single cells in situ Every year at the Advances of Genome Biology and Technology you can see what the future holds. When long-read sequencing was introduced in 2011, people here at AGBT19 are still talking about that Pacific Biosciences fireworks display on the … Read more
Here at the American Society for Human Genetics (#ASHG18) it has been several years since I’ve attended. The exhibit hall is as large as ever, plenty of new firms in DTC (Direct To Consumer) genomics, bioinformatics, and other technical feats are out in full-force. The new Singlera website is now live. What has been fun … Read more
Can a graphene biosensor company like Cardea Biosciences play a role in making P4 medicine (predictive, preventive, personalized and participatory medicine) a reality? Lee Hood’s vision for P4 medicine It was about six years ago I attended a Personalized Healthcare conference at Virginia Commonwealth University in Richmond Virginia, where Leroy Hood of the Institute of … Read more