Do you listen to podcasts? Would you be interested in learning about how Olink Proteomics’ technology is applied in biomarker discovery, drug discovery, proteogenomics, and routine research into biological mechanisms? If so, here’s the first ‘teaser’ advertisement, and we will be launching the first episode in a week. You can listen to the episode by … Read more
Promising technology out of UCSF to use droplets as containers for single-cell interaction assays Way back in 2009 I remember the first time my sales manager at RainDance Technologies presented their core technology to a sophisticated group at the US National Institutes of Health, with an introduction to microfluidics. He began by saying “Microfluidics has … Read more
A direct-to-consumer COVID-19 test available via Amazon with a convenient saliva sample-type and fast central-laboratory processing The current environment for this third (or is it fourth) wave of COVID-19 SARS-CoV-2 infections is reaching new records. The first week of January 2021 is seeing a 7-day moving average of cases above 234,000 per day (the prior … Read more
Abbott’s new $5, 15-minute, 50 million per month test is a game-changer This past week an eventful announcement came from Abbott Laboratories, manufacturer of several diagnostic platforms, including several already approved fro COVID-19 testing including amplification-based IDNow, and a few antibody automated systems, one prominent one being the Architect. Now on their Binax platform, which … Read more
It was about a year ago that I highlighted here some neat graphene technology out of Cardea Biosciences, and in that context I mentioned CRISPR-based diagnostics. (If interested, you can find the post here.) The FDA recently approved under Emergency Use Authorization (EUA) Sherlock BioSciences’ SARS-CoV-2 Rapid diagnostic (FDA EUA page is here) and let’s … Read more
Cardea Bio Inc. and Nanosens Innovations Inc., Keck Graduate Institute and UC Berkeley detect two deleted DMD exons in 15 minutes down to 1.7 fM sensitivity We are currently living in an exciting time in molecular diagnostics, as the fields of chemical fluorescence, optics, electronics, microfluidics, biochemistry, genomics and nanofabrication intersect and produce surprising synergies. … Read more
Here at the American Society for Human Genetics (#ASHG18) it has been several years since I’ve attended. The exhibit hall is as large as ever, plenty of new firms in DTC (Direct To Consumer) genomics, bioinformatics, and other technical feats are out in full-force. The new Singlera website is now live. What has been fun … Read more
Announcing a big move for Dale affecting his family, his employer, his colleagues, and his friends Note: This article originally appeared on LinkedIn. The magic wand of early detection Several years ago at a meeting with sales management, someone asked a provocative question: “If you had a magic wand, what would you ask for?” If … Read more
Two Pore Guys (2PG) has come a long way in a little over 18 months Background of Two Pore Guys At the recent Next Generation Diagnostics Conference in Washington DC (#NGDx18) Two Pore Guys had a nice exhibit where I had the privilege of meeting Tyler Shropshire Ph.D., their Sr. Scientific Manager of R&D. It … Read more
Background Back in 1989 in Belgrade Yugoslavia, Radoje Drmanac had an idea that would shape the next decade of genetic analysis, which was being able to sequence megabases of DNA information by a collection of 11-mers to 20-mers. Doing the mathematical calculations, this paper lays out what kind of DNA oligonucleotides would be needed to … Read more
Now that another year has passed it is great to see the NanoString Digital Spatial profiling microscope near its commercial launch. The platform will be in early access to select customers in the fourth quarter of 2018, and full commercial launch in the first half of 2019. For those interested in accessing the technology, they … Read more
John Iafrede (Massachusetts General Hospital, MA) “There is a tidal wave of cell-free approaches; little performance testing; and the big question is who is going to pay for it.” This year’s Assocation for Molecular Pathology was held in Salt Lake City, Utah from November 15-18, 2017. (You can find the 2017 program and abstract here.) … Read more