High-content imaging continues to be a theme, and will Hi-C become a popular research tool? Yesterday Akoya Biosciences showed a system that could do 50 fluorescent markers for high-content imaging of tissue samples, with a separate stage the mounts on an existing fluorescent microscope. Nanostring also celebrated the GeoMx launch complete with an evening launch … Read more
Akoya Biosciences offers 50+ protein markers along with existing Phenoptics offering, while Berkeley Lights has a unique single-cell, live-cell analysis platform Every year the American Association for Cancer Research conference is a major conference for major product announcements and new companies to test the cancer research market. And while walking around the exhibit floor, you … Read more
Cardea Bio Inc. and Nanosens Innovations Inc., Keck Graduate Institute and UC Berkeley detect two deleted DMD exons in 15 minutes down to 1.7 fM sensitivity We are currently living in an exciting time in molecular diagnostics, as the fields of chemical fluorescence, optics, electronics, microfluidics, biochemistry, genomics and nanofabrication intersect and produce surprising synergies. … Read more
Automation may seem a straightforward task, for those who have not tackled it before As an attendee of Advances in Genome Biology and Technology (#AGBT19) there are plenty of new things to check out, and while it may not be as cutting edge as spatial genomics or mRNA isoform discovery from long single-molecule reads, liquid … Read more
An unusual presentation by a recently-retired NASA scientist Dr. John Charles shares an unusual and highly entertaining presentation entitled “From here to Mars: How the Twins Study and the year-long ISS mission have moved us closer to the red planet” The agenda of AGBT runs a wide range of topics, from the highly specific on … Read more
NGHRI’s Dr. Adam Phillippy presents a remarkable dataset – the telomere-to-telomere assembly of a complete human X chromosome When the completion of the Human Genome Project was announced on June 6, 2002, President Bill Clinton said the following: We are here to celebrate the completion of the first survey of the entire human genome. Without … Read more
A Wellcome Trust supported effort, The Long Read Club seeks to resurrect a time-honored tradition: protocol development After a long 5 days away from home and work and the routines that surround it, attending AGBT (and likewise other major conferences) is a tremendous amount of work. I was teasing a division lead for a major … Read more
According to one thought-leader, it was the highlight of Advances of Genome Biology and Technology 2019 in Marco Island FL Way back in 1997 Craig Venter and Daniel Cohen (co-founder of Millenium Pharmaceuticals, among other things) wrote an essay entitled ‘The Century of Biology’. Here we are a little under twenty years into this new … Read more
Single-cell isoforms from long-reads take the stage at the Advances for Genome Biology and Technology, along with structural variation and better reference genomes. Underlying all these advances is better long-read technology from Pacific Biosciences and Oxford Nanopore. Thinking a little further about the overarching theme of this year’s Advances in Genome Biology and Technology conference … Read more
At #AGBT19 there is a palpable movement from dissociated single cells to single cells in situ Every year at the Advances of Genome Biology and Technology you can see what the future holds. When long-read sequencing was introduced in 2011, people here at AGBT19 are still talking about that Pacific Biosciences fireworks display on the … Read more
A commercial platform for droplet genomics Once upon a time Fluidigm had a single-system called the C1. Okay, it was back in September of 2013 that I wrote about it here; reading what I wrote way back then over five years ago there are newer and improved SMARTer cDNA kits (take a look at this … Read more
There may still be room in NGS for innovation in workflow A few years ago Illumina’s Scientific Affairs team put together a gigantic wall-poster of all the different types of library preparation methods for next-generation sequencing (NGS). Today there are no less than three posters (one for DNA, one for RNA, and a third for … Read more